Cancers familiaux et cancers héréditaires - Institut Jules Bordet ...

ASCO 2005HIGHLIGHTS OF THE 2005 ASCO ANNUAL MEETINGGilberto de Castro Jr., Ahmad Awada,Clinique d’Oncologie Médicale, Institut Jules BordetAmong the more than 9500 abstracts published in the Proceedings of the 2005Annual Meeting of the American Society of Clinical Oncology, we present those whorepresent a new standard of care of solid tumors. The first author and the number ofeach abstract are mentioned. The reader is invited to consult the original abstractspublished in J Clin Oncol 23 (16S).Breast CancerLeach (520): Magnetic resonance imaging (MRI)was found to be more sensitive than conventionalmammography in breast cancer (BC) detectionin high-risk patients (pts) and specifically in thesubgroup of BRCA1 carriers, suggesting that MRImust be added to the screening of BC in thisgroup of pts.Baxter (516):The rate of invasive ipsilateral BC at8 years in 10,034 women diagnosed with ductalcarcinoma in situ (DCIS) submitted to lumpectomyonly was 6.2% versus (vs.) 2.7% in thosetreated also by radiation therapy (RT, HR 0.43),supporting the routine use of RT after lumpectomyfor DCIS.Paik (510): Using the 21-gene recurrence score(RS) assay Oncotype DX, it was showed that thebenefit of adjuvant treatment with tamoxifenin terms of better 10-year distant-recurrencefree survival in the study NSABP B-14 was confinedto the pts with low (RS