Products at a Glance 2024

www.pelobiotech.com

www.pelobiotech.com lymphangiogenesis in a lymphatic organotypic co-culture model, providing valuable insights into the mechanisms underlying lymphatic vessel formation in the context of tumor microenvironment. Endothelial cells from the lymphatic system have been extensively studied for their role in lymphangiogenesis and the development of the lymphatic vasculature. Studies have demonstrated that Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate, highlighting its essential role in the induction of the lymphatic endothelial cell phenotype. The expression of podoplanin in stromal fibroblasts has been associated with high lymphatic vessel density in triple-negative, basal marker-expressing, and high-grade breast carcinomas, indicating its potential as a marker for lymphatic endothelial cells and lymphangiogenesis. The differential response of lymphatic endothelial cells to angiopoietin-1 and angiopoietin-2 has been investigated, providing insights into the molecular regulation of lymphangiogenesis and the distinct functions of angiopoietins in lymphatic vessel development. Skeletal system We offer a variety of synovial cells, chondrocytes, osteoblasts, endothelial cells from various vessels, and tenocytes sourced from different animal species, with cell RNA from adults and fetuses all of which are extracted from various bones. Synovial cells have been studied for their modulatory effect on cell phenotype and metabolic behavior in osteoarthritic patients, providing insights into the inflammatory and metabolomic profile of synovial fluid and its impact on synovial cell behavior. Additionally, the inflammatory response of synovial fibroblasts has been investigated, shedding light on the regulation of synovial cell growth by polypeptide growth factors. Chondrocytes have been extensively utilized in the study of cartilage regeneration and the development of high-quality cartilage. Studies have focused on the potential of aged human articular chondrocytes for cartilage regeneration, aiming to reverse chondrocyte aging and enhance cartilage regeneration. Furthermore, the role of microRNA-224 in suppressing osteoblast differentiation by inhibiting SMAD4 has been investigated, providing insights into the molecular mechanisms underlying osteoblast differentiation and function. Osteoblasts have been studied for their role in bone formation and bone-related diseases, with a focus on the regulation of osteoblast proliferation and differentiation. The knockout of the BK channel in osteoblasts has been investigated to determine its impact on osteoblast function and bone formation. The proliferative actions of parathyroid hormonerelated protein (PTHrP) in chondrocytes have been studied, highlighting the role of the cyclin-dependent kinase inhibitor p57Kip2 in mediating PTHrP-induced proliferation in chondrocytes. Circulatory system We provide a diverse array of cells from different animal species, isolated from various arteries and veins. Our offerings include endothelial cells, MSCs, fibroblasts, peripheral blood cells with a variety of markers, NK cells, monocytes, and blood cells. Additionally, we offer MSCs with GFP and RFP tags, as well as smooth muscle cells, with available cell RNA. Mesenchymal stem cells (MSCs) have been extensively studied and utilized in various research and clinical applications due to their regenerative and immunomodulatory properties. MSCs have been identified and isolated from different sources, including the umbilical cord, bone marrow, adipose tissue, and other tissues. These cells have shown potential for use in tissue engineering, regenerative medicine, and immunotherapy. The expression of specific surface markers and the characterization of MSCs from various sources have been the focus of numerous studies, aiming to understand their properties and potential applications. Peripheral blood cells with a variety of markers have been extensively studied for their role in the immune response and as a source of hematopoietic stem cells. These cells have been used in the study of immune cell populations, including T cells, B cells, and natural killer (NK) cells. The expression of specific markers on peripheral blood cells has been investigated to understand their functions and to develop targeted therapies for various diseases. NK cells, a type of cytotoxic lymphocyte, have been studied for their role in the immune response against infected or malignant cells. These cells have been investigated for their potential use in cancer immunotherapy and as a treatment for viral infections. The expression of specific markers on NK cells has been studied to understand their activation and cytotoxic functions. Monocytes, which are a type of white blood cell, have been extensively studied for their role in the immune response and as precursors to macrophages and dendritic cells. These cells have been investigated for their potential use in immunotherapy and as a source of antigen-presenting cells. The expression of specific markers on monocytes has been studied to understand their differentiation and immune functions. 22

www.pelobiotech.com Muscles We provide a diverse range of skeletal muscle cells and endothelial cells from various tissues and individuals, including diseased muscle cells and osteoblasts from different species. Additionally, we offer total RNA from skeletal muscle tissues, multinucleated myotubes, and RNA from stimulated or differentiated osteoblasts. Skeletal muscle cells have been extensively studied for their role in muscle regeneration, myogenesis, and the development of tissue engineering strategies for muscle repair. These cells have been used to investigate the molecular mechanisms underlying muscle development, regeneration, and the pathogenesis of muscle-related disorders. Total RNA from skeletal muscle tissues has been utilized in gene expression studies, transcriptome profiling, and the identification of regulatory pathways involved in muscle development, function, and disease. These studies have provided insights into the molecular signatures of skeletal muscle tissues and the dynamic changes in gene expression during myogenesis and muscle regeneration. Multinucleated myotubes, which are formed during myogenesis, have been studied for their role in muscle development, contractile function, and the regulation of muscle-specific gene expression. These structures have been used as an in vitro model to investigate muscle differentiation, fusion, and the molecular events underlying myotube formation. Differentiated osteoblasts have been extensively utilized in the study of bone formation, mineralization, and the regulation of skeletal development. These cells have been investigated for their potential role in bone tissue engineering, the study of osteogenesis, and the identification of molecular pathways involved in bone remodeling and repair. Scan the QR code to see our full cell list. Custom Cell Isolation Researchers seeking tailored solutions can benefit from our custom cell isolation services. We offer the flexibility to use our standard protocols or your preferred methods, all at affordable rates. For precise cell isolation, we recommend our top-quality VitaCyte enzymes, particularly when working with sensitive cells or when accurate surface marker expression is essential, as in the case of hepatocytes. 23