WAAR WIJ TROTS OP ZIJN
WAAR WIJ TROTS OP ZIJN
WAAR WIJ TROTS OP ZIJN
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Entropy of Class-A GPCRs<br />
3<br />
2<br />
1<br />
0<br />
0<br />
3.32<br />
6.37<br />
5.48<br />
3.25<br />
3.50<br />
3.43<br />
5.35<br />
4.47<br />
Binding site<br />
Conserved<br />
Extracellular end of helices<br />
Helix-helix interaction<br />
Facing membrane<br />
Mixed region<br />
20 40 60<br />
Sum of subfamilies’ entropies<br />
Clustering positions in the two-entropies plot into different<br />
functional categories. The magenta dots ◆, for instance, refer<br />
to individual amino acids that are highly conserved, probably<br />
playing a role in the activation mechanism of the receptors.<br />
Numbers refer to specific amino acid positions in the receptors,<br />
such as red-dotted 3.32 ● in the third trans-membrane domain,<br />
which supposedly plays an important role in drug binding.<br />
The red dots ● in the two-entropies plot correspond to the red<br />
amino acids ✕ in the receptor structure. They are lining the<br />
(yellow) ligand-binding site.<br />
39
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