Videnskabelig årsrapport 2005 - Rigshospitalet

Diagnostisk Center
Susanne Smed
Tina Axen
Vigtigste satsningsområder
inden for forskningen
Ekspressionsregulation af biologisk aktive
peptider.
Diagnostik af sygdomsgener.
Vaskulær biologi.
Transkriptionsfaktorer i cellevækst og
differentiering.
Transgene mus som sygdomsmodeller.
Transgene musemodeller for signal
transduction pathways.
Sygdomsmekanismer ved leukæmi.
Nonsense-mediated mRNA decay: et
genomisk overvågnings system.
Publikationer
Disputatser og ph.d.-afhandlinger
forsvaret i året
Goetze, J. P. ProBNP-derived peptides in
plasma: From the endocrine heart to
cardiac disease (disputats).
København: Lægeforeningens Forlag;
2005:1-97. Forsvaret den 26/8 2005
ved Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Videnskabelige artikler
A. Førsteforfatter fra
forskningsenheden
Benn M, Nordestgaard BG, Jensen JS,
Nilausen K, Meinertz H, Tybjaerg-
Hansen A. Mutation in
apolipoprotein B associated with
hypobetalipoproteinemia despite
decreased binding to the low density
lipoprotein receptor. J Biol Chem
2005;280(22):21052-60.
Benn M, Nordestgaard BG, Jensen JS,
Grande P, Sillesen H, Tybjaerg-
Hansen A. Polymorphism in APOB
associated with increased low-density
lipoprotein levels in both genders in
the general population. J Clin
Endocrinol Metab 2005;90(10):5797-
803.
Bro S, Nielsen LB. Hjertekarsygdom. In:
Eidemark I, ed. Dialyse. Århus:
FADL's Forlag; 2005:193-212.
Bro S, Rasmussen Å. Hormonelle
forstyrrelser og seksuel dysfunktion.
In: Eidemark I, ed. Dialyse. Århus:
FADL's Forlag; 2005:228-34.
Friis-Hansen L, Wierup N, Rehfeld JF,
Sundler F. Antral G-cell in gastrin
and gastrin-cholecystokinin knockout
animals. Cell Tissue Res
2005;321(1):141-6.
Friis-Hansen L. Indførelse af 1. trimester
screening med dobbelt-test. Klinisk
Biokemi i Norden 2005;17(4):14-25.
Friis-Hansen L, Wierup N, Rehfeld JF,
Sundler F. Reduced ghrelin, islet
amyloid polypeptide, and peptide YY
expression in the stomach of gastrincholecystokinin
knockout mice.
Endocrinology 2005;146(10):4464-
71.
Frikke-Schmidt R, Nordestgaard BG,
Schnohr P, Steffensen R, Tybjaerg-
Hansen A. Mutation in ABCA1
predicted risk of ischemic heart
disease in the Copenhagen City Heart
Study Population. J Am Coll Cardiol
2005;46(8):1516-20.
Goetze JP, Rehfeld JF, Videbaek R, Friis-
Hansen L, Kastrup J. B-type
natriuretic peptide and its precursor
in cardiac venous blood from failing
hearts. Eur J Heart Fail 2005;7(1):69-
74.
Goetze JP. Coronary artery disease, heart
failure, and cardiac natriuretic
peptides in the middle. Eur Heart J
2005;26(24):2603-4.
Goetze JP, Paloheimo LI, Linnala A,
Sipponen P, Hansen CP, Rehfeld JF.
Gastrin-17 specific antibodies are too
specific for gastrinoma diagnosis but
stain G-cells. Scand J Gastroenterol
2005;40(5):596-8.
Goetze JP. Hjertets egne hormoner.
Klinisk Biokemi i Norden 2005;17:8-
10.
Goetze JP, Videbaek R. More hormones
spilt in heart failure: linking renal
sympathetic activation to clinical
outcome. Eur Heart J
2005;26(9):861-2.
Halse KG, Lindegaard ML, Goetze JP,
Damm P, Mathiesen ER, Nielsen LB.
Increased plasma pro-B-type
natriuretic peptide in infants of
women with type 1 diabetes. Clin
Chem 2005;51(12):2296-302.
Hammer NA, Hansen TO, Byskov AG,
Rajpert-De ME, Grondahl ML,
Bredkjaer HE, et al. Expression of
IGF-II mRNA-binding proteins
(IMPs) in gonads and testicular
cancer. Reproduction
2005;130(2):203-12.
Lindegaard ML, Olivecrona G,
Christoffersen C, Kratky D, Hannibal
J, Petersen BL, et al. Endothelial and
lipoprotein lipases in human and
mouse placenta. J Lipid Res
2005;46(11):2339-46.
Lindegaard ML, Nielsen JE, Hannibal J,
Nielsen LB. Expression of the
endothelial lipase gene in murine
embryos and reproductive organs. J
Lipid Res 2005;46(3):439-44.
Nielsen LB, Goetze JP. Letters regarding
article by Bibbins-Domingo et al, "Btype
natriuretic peptide and ischemia
in patients with stable coronary
disease: data from the Heart and Soul
study". Circulation 2005;111(2):e15.
Nielsen SJ, Rehfeld JF, Pedersen F,
Kastrup J, Videbaek R, Goetze JP.
Measurement of pro-C-type
natriuretic peptide in plasma. Clin
Chem 2005;51(11):2173-6.
Porse BT, Bryder D, Theilgaard-Monch
K, Hasemann MS, Anderson K,
Damgaard I, et al. Loss of C/EBP
alpha cell cycle control increases
myeloid progenitor proliferation and
transforms the neutrophil granulocyte
lineage. J Exp Med 2005;202(1):85-
96.
Rehfeld JF. Forskeren og loyalitet. Bibl
Læger 2005;197:257-68.
Rehfeld JF, Goetze JP. Galdesten som
symptom på CCK resistens. Ugeskr
Læger 2005;167:2658-9.
Rehfeld JF. H-indekset, en finurlig
bibliometrisk parameter. Ugeskr
Læger 2005;167(47):4479.
Rehfeld JF. Visfatin og den totale
endokrinologi. Ugeskr Læger
2005;167(25-31):2793-4.
Sethi AA, Tybjaerg-Hansen A, Jensen
GB, Nordestgaard BG. 164Ile allele
in the beta2-Adrenergic receptor gene
is associated with risk of elevated
blood pressure in women. The
Copenhagen City Heart Study.
Pharmacogenet Genomics
2005;15(9):633-45.
Theilgaard-Monch K, Jacobsen LC,
Rasmussen T, Niemann CU, Udby L,
Borup R, et al. Highly glycosylated
alpha1-acid glycoprotein is
synthesized in myelocytes, stored in
secondary granules, and released by
activated neutrophils. J Leukoc Biol
2005;78(2):462-70.
Theilgaard-Monch K, Jacobsen LC,
Borup R, Rasmussen T, Bjerregaard
MD, Nielsen FC, et al. The
transcriptional program of terminal
granulocytic differentiation. Blood
2005;105(4):1785-96.
Tybjaerg-Hansen A, Jensen HK, Benn M,
Steffensen R, Jensen G, Nordestgaard
BG. Phenotype of heterozygotes for
low-density lipoprotein receptor
mutations identified in different
background populations. Arterioscler
Thromb Vasc Biol 2005;25(1):211-5.
Zaina S, Dossing KB, Lindholm MW,
Lund G. Chromatin modification by
lipids and lipoprotein components: an
initiating event in atherogenesis?
Curr Opin Lipidol 2005;16(5):549-
53.
Zaina S, Lindholm MW, Lund G.
Nutrition and aberrant DNA
methylation patterns in
atherosclerosis: more than just
hyperhomocysteinemia? J Nutr
2005;135(1):5-8.
B. Medforfatter fra forskningsenheden
Benfield TL, Dahl M, Nordestgaard BG,
Tybjaerg-Hansen A. Influence of the
factor V Leiden mutation on
infectious disease susceptibility and
outcome: a population-based study. J
Infect Dis 2005;192(10):1851-7.
Bojesen SE, Kjaer SK, Hogdall EV,
Thomsen BL, Hogdall CK, Blaakaer
J, et al. Increased risk of ovarian
cancer in integrin beta3 Leu33Pro
homozygotes. Endocr Relat Cancer
2005;12(4):945-52.
Bojesen SE, Tybjaerg-Hansen A,
Axelsson CK, Nordestgaard BG. No
association of breast cancer risk with
integrin beta3 (ITGB3) Leu33Pro
genotype. Br J Cancer
2005;93(1):167-71.
Borregaard N, Theilgaard-Monch K,
Cowland JB, Stahle M, Sorensen OE.
Neutrophils and keratinocytes in
innate immunity--cooperative actions
to provide antimicrobial defense at
the right time and place. J Leukoc
Biol 2005;77(4):439-43.
Chen D, Friis-Hansen L, Hakanson R,
Zhao CM. Genetic dissection of the
signaling pathways that control
gastric acid secretion.
Videnskabelig årsrapport 11