Videnskabelig årsrapport 2005 - Rigshospitalet

Finsencentret
thrombocytopenic purpura. Am J
Hematol 2005;78(4):275-80.
Bukh A, D'Amore FA, Gimsing P,
Hasselbalch HC, Johnsen HE,
Kerndrup GB, et al. [Designer drugs
and their rational use in clinical
hematology]. Ugeskr Laeger
2005;167(20):2180-3.
Carlson K, Hjorth M, Knudsen LM.
Toxicity in standard melphalanprednisone
therapy among myeloma
patients with renal failure--a
retrospective analysis and
recommendations for dose
adjustment. Br J Haematol
2005;128(5):631-5.
Franklin J, Paus M, Pluetschow A, Specht
L, Franklin J. Chemotherapy,
radiotherapy and combined modality
for Hodgkin's disease, with emphasis
on second cancer risk. Cochrane
Database Syst Rev
2005;(4):CD003187.
Gombart AF, Borregaard N, Koeffler HP.
Human cathelicidin antimicrobial
peptide (CAMP) gene is a direct
target of the vitamin D receptor and
is strongly up-regulated in myeloid
cells by 1,25-dihydroxyvitamin D3.
FASEB J 2005;19(9):1067-77.
Heilborn JD, Nilsson MF, Jimenez CI,
Sandstedt B, Borregaard N, Tham E,
et al. Antimicrobial protein
hCAP18/LL-37 is highly expressed in
breast cancer and is a putative growth
factor for epithelial cells. Int J Cancer
2005;114(5):713-9.
Hudlebusch HR, Theilgaard-Monch K,
Lodahl M, Johnsen HE, Rasmussen
T. Identification of ID-1 as a
potential target gene of MMSET in
multiple myeloma. Br J Haematol
2005;130(5):700-8.
Hutchings M, Loft A, Hansen M,
Pedersen LM, Buhl T, Jurlander J, et
al. FDG-PET after two cycles of
chemotherapy predicts treatment
failure and progression-free survival
in Hodgkin lymphoma. Blood
2006;107(1):52-9.
Hvidberg V, Jacobsen C, Strong RK,
Cowland JB, Moestrup SK,
Borregaard N. The endocytic receptor
megalin binds the iron transporting
neutrophil-gelatinase-associated
lipocalin with high affinity and
mediates its cellular uptake. FEBS
Lett 2005;579(3):773-7.
Kollgaard T, Petersen SL, Hadrup SR,
Masmas TN, Seremet T, Andersen
MH, et al. Evidence for involvement
of clonally expanded CD8+ T cells in
anticancer immune responses in CLL
patients following nonmyeloablative
conditioning and hematopoietic cell
transplantation. Leukemia
2005;19(12):2273-80.
Mauch P, Ng A, Aleman B, Carde P,
Constine L, Diehl V, et al. Report
from the Rockefellar Foundation
Sponsored International Workshop
on reducing mortality and improving
quality of life in long-term survivors
of Hodgkin's disease: July 9-16,
2003, Bellagio, Italy. Eur J Haematol
Suppl 2005;(66):68-76.
Porse BT, Bryder D, Theilgaard-Monch
K, Hasemann MS, Anderson K,
Damgaard I, et al. Loss of C/EBP
alpha cell cycle control increases
myeloid progenitor proliferation and
transforms the neutrophil granulocyte
lineage. J Exp Med 2005;202(1):85-
96.
Poulsen CB, Borup R, Nielsen FC,
Borregaard N, Hansen M, Gronbaek
K, et al. Microarray-based
classification of diffuse large B-cell
lymphoma. Eur J Haematol
2005;74(6):453-65.
Simonsson B, Oberg G, Bjoreman M,
Bjorkholm M, Carneskog J, Karlsson
K, et al. Intensive treatment and stem
cell transplantation in chronic
myelogenous leukemia: long-term
follow-up. Acta Haematol
2005;113(3):155-62.
Vijay-Kumar M, Gentsch JR, Kaiser WJ,
Borregaard N, Offermann MK, Neish
AS, et al. Protein kinase R mediates
intestinal epithelial gene remodeling
in response to double-stranded RNA
and live rotavirus. J Immunol
2005;174(10):6322-31.
Institut for
Inflammationsforskning
(IIR)
* Tilknyttet andre afdelinger/centre på
Rigshospitalet, men lægger væsentlig
forskningsvirksomhed i Institut for
Inflammationsforskning.
Videnskabeligt personale
Seniorforskere
Professor, overlæge, dr.med. Klaus
Bendtzen
Overlæge Vagn Andersen
Civilingeniør, cand.polyt., ph.d. Lone
Frier Bovin
Afdelingslæge, dr.med. Klaus G. Müller*
Cand.scient., hum.biol., ph.d. Jacob
Nersting
Læge, cand.scient., ph.d. Claus Henrik
Nielsen*
Laboratoriechef, cand.scient. Morten
Svenson
Ph.d.-studerende
Læge Morten Breindahl
Læge Daniel el Fassi
Cand.scient. Pia Galle
Cand.scient. Chris Juul Hedegaard
Tandlæge Tanja Skuldbøl
Cand.scient. Anna Margrethe Ejrnæs
Sprinkel
Cand.scient. Søren Ulrik Salling Sønder
Cand.scient. Lars K. Sørensen
Udenlandske gæsteforskere
Associate professor, MD, Ning Chen,
Tianjin, P.R. China
Professor, MD, Ferdinando Nicoletti,
Catania, Italien
Andre forskere
Civilingeniør, cand.polyt. Christian
Enevold-Johansen
Kemiingeniør Louise Birch Hansen
Cand.scient. Morten Løbner Pedersen
Læge Klaus Rieneck*
Læge Christian Ross*
Studenterforskere
Birgitte Bjørnhart
Sune Damgård
Benjamin Gilbert-Jespersen
Marianne Mikkelsen
Øvrigt forskningspersonale
Kirsten Andersen
Lone Bredahl
Ole Christensen
Winnie Hansen
Pia Grothe Meinke
Marianna Thomsen
Merete Tjalve
Vigtigste satsningsområder
inden for forskningen
Genekspression (GeneChips).
Cellevækst, -død.
Signalpeptider (cytokiner).
Komplement og komplementreceptorer,
B- og T-lymfocytaktivering.
Antigenpræsentation, dendritceller,
vaccination.
Patogenetiske mekanismer ved infektiøse
og immuninflammatoriske
sygdomme, bl.a. leddegigt, slidgigt,
allergi, arteriosklerose, cancer.
Behandlingsmetoder ved
immuninflammatoriske sygdomme.
Immunogenicitet af biofarmaka,
monitorering af behandling.
Publikationer
Disputatser og ph.d.-afhandlinger
forsvaret i året
Breindahl M. Inflammatory mediators in
infants infected with respiratory
syncytial virus (RSV). A prospective,
cohort study in a one-centre
secondary setting (ph.d.-afhandling).
København: Eget forlag; 2005: 1-85.
Forsvaret den 17/6 2005 ved
Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Galle P. Natural and induced interleukin-6
autoantibodies (ph.d.-afhandling).
København: Eget forlag; 2005:1-45.
Forsvaret den 10/6 2005 ved
Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Sprinkel AME. IgG-mediated efects of
specific immunotherapy: Blocking
properties of IgG subclasses and
binding to FcgammaRIIB on
basophils (ph.d.-afhandling).
København: Eget forlag; 2005: 1-78.
Forsvaret den 17/8 2005 ved
Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Videnskabelige artikler
A. Førsteforfatter fra
forskningsenheden
Andersen J, Heilmann C, Jacobsen N,
Bendtzen K, Müller K. Cytokines and
soluble tumour necrosis factor I
receptor levels during pretransplant
conditioning in allogeneic stem-cell
30 Videnskabelig årsrappport