Videnskabelig årsrapport 2005 - Rigshospitalet

Finsencentret
transplantation. Int
Immunopharmacol 2005;5:67-71.
Bjørnhart B, Svenningsen P,
Gudbrandsdottir S, Zak M, Nielsen S,
Bendtzen K, Müller K. Plasma TNF
binding capacity in patients with
juvenile idiopathic arthritis. Int
Immunopharmacol 2005;5:73-7.
el Fassi D, Nielsen CH, Hasselbalch HC,
Hegedüs L. Succesful B lymphocyte
depletion with Rituximab in a patient
with recurrent Graves' disease and
severe ophthalmopathy. Thyroid
2005;15:S28-9.
Nicoletti F, Creange A, Orlikowski D,
Bolgert F, Mangano K, Metz C, Di
Marco R, Al Abed Y. Macrophage
migration inhibitory factor (MIF)
seems crucially involved in Guillain-
Barre syndrome and experimental
allergic neuritis. J Neuroimmunol
2005;168:168-74.
Nielsen CH, Leslie RGQ. Regulation of
B-Cell Activation by Complement
Receptors and Fc Receptors. Transfus
Med Hemother 2005;32:339-47.
Nielsen CH, Marquart HV, Leslie RGQ.
The role of complement in immune
and autoimmune responses. Transfus
Med Hemother 2005;32:68-82.
B. Medforfatter fra forskningsenheden
Al-Abed Y, Dabideen D, Aljabari B,
Valster A, Messmer D, Ochani M,
Tanovic M, Ochani K, Bacher M,
Nicoletti F, Metz CN, Pavlov VA,
Miller EJ, Tracey KJ. ISO-1 binding
to the tautomerase active site of MIF
inhibits its pro-inflammatory activity
and increases survival in severse
sepsis. J Biol Chem 2005;280:36541-
4.
Andersen P, Permin H, Andersen V,
Schejbel L, Garred P, Svejgaard A,
Barington T. Deficiency of somatic
hypermutation of the antibody light
chain is associated with increased
frequency of severe respiratory tract
infection in common variable
immunodeficiency. Blood
2005;105:511-7.
Bodtger U, Ejrnaes AM, Hummelshoj L,
Jacobi HH, Poulsen LK, Svenson M.
Is immunotherapy-induced birchpollen-specific
IgG4 a marker for
decreased allergen-specific
sensitivity? Int Arch Allergy
Immunol 2005;136:340-6.
Conget I, Aguilera E, Pellitero S, Näf S,
Bendtzen K, Casamitjana R, Gomis
R, Nicoletti F. Lack of effect of
intermittently administered sodium
fusidate to patients with newly
diagnosed type 1 diabetes mellitus:
the FUSIDIM trial. Diabetologia
2005;48:1464-8.
Cvetkovic I, Al-Abed Y, Miljkovic D,
Maksimovic-Ivanic D, Roth J, Bacher
M, Lan HY, Nicoletti F, Stosic-
Grujicic S. Critical Role Macrophage
Migration Inhibitory Factor (MIF)
Activity in Experimental
Autoimmune Diabetes.
Endocrinology 2005;146:2941-51.
De Carvalho Bittencourt M, Herren S,
Graber P, Vilbois F, Pasquali C,
Berney C, Plitz T, Nicoletti F, Kosco-
Vilbois MH. Extracellular lysosomeassociated
membrane protein-1
(LAMP-1) mediates autoimmune
disease progression in the NOD
model of type 1 diabetes. Eur J
Immunol 2005;35:1501-9.
Grauballe MC, Bentzen BH, Bjornsson
M, Moe D, Jonassen TE, Bendtzen K,
Stoltze K, Holmstrup P. The effect of
spironolactone on experimental
periodontitis in rats. J Periodontal
Res 2005;40:212-7.
Havemose-Poulsen A, Sørensen LK,
Stoltze K, Bendtzen K, Holmstrup P.
Cytokine profiles in peripheral blood
and whole blood cell cultures
associated with aggressive
periodontitis, juvenile idiopathic
arthritis, and rheumatoid arthritis. J
Periodontol 2005;76:2276-85.
Lindqvist E, Eberhardt K, Bendtzen K,
Heinegard D, Saxne T. Prognostic
laboratory markers of joint damage in
rheumatoid arthritis. Ann Rheum Dis
2005;64:196-201.
Nielsen CH; Marquart HV; Quinton
RGQ. Der Einfluss des
Komplementsystems auf die Immunund
Autoimmunantwort. Transfus
Med Hemother 2005;31:68-82.
Papaccio G, Graziano A, Valiante S,
D'Aquino R, Travali S, Nicoletti F.
Interleukin (IL)-1beta toxicity to islet
beta cells: Efaroxan exerts a complete
protection. J Cell Physiol
2005;203:94-102.
Pedersen MW, Pedersen N, Damstrup L,
Villingshoj M, Sonder SU, Rieneck
K, Bovin LF, Spang-Thomsen M,
Poulsen HS. Analysis of the
epidermal growth factor receptor
specific transcriptome: effect of
receptor expression level and an
activating mutation. J Cell Biochem
2005;96:412-27.
Schejbel L, Marquart H, Andersen V,
Permin H, Andersen P, Svejgaard A,
Barington T. Deficiency of somatic
hypermutation of immunoglobulin G
transcripts is a better predictor of
severe respiratory tract infections
than lack of memory B cells in
common variable immunodeficiency.
J Clin Immunol 2005;25:392-403.
Sellebjerg F, Ross C, Koch-Henriksen N,
Sørensen PS, Frederiksen JL,
Bendtzen K, Sørensen TL.
CD26+CD4+ T cell counts and attack
risk in interferon-treated multiple
sclerosis. Mult Scler 2005;11:641-5.
Sorensen PS, Koch-Henriksen N, Ross C,
Clemmesen KM, Bendtzen K, The
Danish Multiple Sclerosis Study
Group. Appearance and
disappearance of neutralizing
antibodies during interferon-beta
therapy. Neurology 2005;65:33-9.
Sorensen PS, Deisenhammer F, Duda P,
Hohlfeld R, Myhr KM, Palace J,
Polman C, Pozzilli C, Ross C.
Guidelines on use of anti-IFN-beta
antibody measurements in multiple
sclerosis: report of an EFNS Task
Force on IFN-beta antibodies in
multiple sclerosis. Eur J Neurol 2005
Nov;12:817-827.
Takahashi N, Rieneck K, van der Kraan
PM, van Beuningen HM, Vitters EL,
Bendtzen K, van den Berg WB.
Elucidation of IL-1/TGF-beta
interactions in mouse chondrocyte
cell line by genome-wide gene
expression. Osteoarthritis Cartilage
2005;13:426-38.
Zaccone P, Phillips J, Conget I, Cooke A,
Nicoletti F. IL-18 binding protein
fusion construct delays the
development of diabetes in adoptive
transfer and cyclophosphamideinduced
diabetes in NOD mouse. Clin
Immunol 2005;115:74-9.
Videnskabelige priser
Klaus Bendtzen: Misse og Valdemar
Risoms Fond til Kræftens
Bekæmpelse 2005.
Onkologisk Klinik og
Radioterapiklinikken
Videnskabeligt personale
Seniorforskere
Overlæge, dr. med. Kell Østerlind
Professor, dr.med. Mikael Rørth
Professor, dr.med. Heine Høi Hansen
Professor, dr.med. Henning T. Mouridsen
Overlæge, dr.med. Gedske Daugaard
Overlæge, dr.med. Hanne Sand Hansen
Overlæge, dr.med. Lena Specht
Overlæge, dr.med. Hans Skovgaard
Poulsen
Overlæge, dr.med. Henrik Roed
Overlæge, dr.med. Jens Benn Sørensen
Overlæge, dr.med. Michael Andersson
Overlæge, dr.med. Peter Buhl Jensen
Overlæge, dr.med. Svend Aage
Engelholm
Overlæge, dr.med. Helle Pappot
Cheffysiker, ph.d. Håkan Nyström
Overlæge, ph.d. Bent Ejlertsen
Overlæge, ph.d. Ulrik Lassen
Overlæge, ph.d. Lars Damstrup
Ph.d.-studerende
Cand.med. Bo Grønlund
Cand.med. Tina Klitmøller Sørensen
Cand.med. Kenneth Hofland
Cand.scient. Karina L. Nielsen
Cand.scient. Lena Ipsen
Cand scient. Marielle Dejligbjerg
Cand.scient. Mikkel Wandahl Pedersen
Cand.scient. Lasse Rye Aarup
Kandidatstipendiat, læge Anders Bilde
Kandidatstipendiat, læge Martin
Hutchings
Malene Fischer
Ulrik Lademann
Siri Beyer
Mogens Grønvold
Anne Sofie Schrol
Videnskabelig assistent, læge Trine
Jakobi Nøttrup
Andre forskere
Lic.scient Nina Pedersen
Stud.scient. Rober Dagil,
specialestuderende
Videnskabelig assistent Søren Astrup
Jensen
Cand.scient., ph.d. Lars Høllund Jensen
Cand.scient., ph.d. Morten Gruslund
Videnskabelig årsrapport 31