Videnskabelig årsrapport 2005 - Rigshospitalet

Finsencentret
Videnskabelige priser
Keld Danø. Thomson Science Citation
Prize 24.05.2005.
Keld Danø. Honorary professor, Fudan
University, Shanghai 28.10.2005.
Hæmatologisk Klinik
Videnskabeligt personale
Seniorforskere
Overlæge, dr.med. Ole Weis Bjerrum
Professor, dr.med. Niels Borregaard
Overlæge, ph.d. Peter de Nully Brown
Cand.scient ph.d. Anne Mette Buhl
Lic.scient. Jack B. Cowland
Overlæge, dr.med. Christian Geisler
Overlæge, dr.med. Peter Gimsing
1. reservelæge, dr.med. Kirsten Grønbæk
Overlæge, dr.med. Mads Hansen
Overlæge, dr.med. Niels Jacobsen
1. reservelæge, ph.d. Jesper Jurlander
Overlæge, dr.med. Lars Kjeldsen
Overlæge, dr.med. Lene Meldgaard
Knudsen
Overlæge, dr.med. Ove Juul Nielsen
Overlæge, dr.med. Henrik Sengeløv
Overlæge, dr.med. Lena Specht
Overlæge, dr.med. Lars Vindeløv
Ph.d.-studerende
Cand.scient. Malene Bjerregaard
Cand.med. Mikkel Faurschou
Cand.cur. Mary Jarden
Cand.med. Pär Josefsson
Cand.med. Carsten Utoft Niemann
Cand.med. Søren Lykke Petersen
Cand.med. Dorthe Tholstrup
Andre forskere
Cand.scient. Pia Klausen
Cand.med. Tania Masmas
Sygeplejerske Tom Møller
Cand.med. Kim Theilgaard-Mönch
Cand.med., ph.d. Lene Udby
Studenterforskere
Stud.scient. Lars Christian Jacobsen
Stud.scient. Anders Holmer Jørgensen
Øvrigt forskningspersonale
Bioanalytiker Lone Bach
Bioanalytiker Anne Bjørlig
Bioanalytiker Charlotte Horn
Bioanalytiker Inge Kobbernagel
Bioanalytiker Lone Pedersen
Vigtigste satsningsområder
inden for forskningen
Alloreaktivitet, immunrekonstitution,
graft-versus-host sygdom, graftversus-leukæmi
effekt.
Autolog stamcelletransplantation,
minimal residual sygdom.
Celle- og molekylærbiologi ved CD5+ B-
celle maligniteter.
Det medfødte immunsystem og myeloide
cellers differentiering.
Bisfosfonaters virkning på apoptose og
cellecyclus i myelomceller.
Genetisk baggrund for malignt lymfom.
Publikationer
Disputatser og ph.d.-afhandlinger
forsvaret i året
Andersen NS. Mantle cell lymphoma -
molecular, biological and clinical
findings (disputats). København: Eget
Forlag; 2005:1-54. Forsvaret den
16/6 2005 ved Københavns
Universitet, Det
Sundhedsvidenskabelige Fakultet.
Jensen MK. Clinical and pathogenetic
aspects of platelet activation in
chronic myeloproliferative disorders
(disputats). København: Eget Forlag;
2005:1-105. Forsvaret den 7/10 2005
ved Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Sørensen OE. The Human Cathelicidin
hCAP-18 (disputats). København:
Lægeforeningens Forlag; 2005:1-15.
Forsvaret den 28/1 2005 ved
Københavns Universitet, Det
Sundhedsvidenskabelige Fakultet.
Videnskabelige artikler
A. Førsteforfatter fra
forskningsenheden
Borregaard N. Antibiotic Molecules:
Intracellular: In: Encylopedia of Life
Sciences. Chichester: John Wiley &
Sons, Ltd.; 2005. Available from:
http://www.els.net/
Borregaard N, Boxer LA. Disorders of
Neutrophil Function. In: Lichtman
MA, Beutler E, Kipps TJ, Seligsohn
U, Kaushansky JT, eds. Williams
Hematology. 7th ed., New York:
McGraw-Hill; 2005:921-57.
Borregaard N, Theilgaard-Monch K,
Cowland JB, Stahle M, Sorensen OE.
Neutrophils and keratinocytes in
innate immunity--cooperative actions
to provide antimicrobial defense at
the right time and place. J Leukoc
Biol 2005;77(4):439-43.
de Nully BP, Jurlander J, Linden O,
Hansen M. [Radioimmunotherapy in
non-Hodgkin's lymphoma. With
focus on anti-CD20 treatment].
Ugeskr Laeger 2005;167(41):3867-9.
Faurschou M, Kamp S, Cowland JB,
Udby L, Johnsen AH, Calafat J, et al.
Prodefensins are matrix proteins of
specific granules in human
neutrophils. J Leukoc Biol
2005;78(3):785-93.
Geisler CH. [Chronic lymphatic
leukemia: primary treatment based on
biological risk stratification. Danish
Society of Hematology]. Ugeskr
Laeger 2005;167(12-13):1392.
Gronbaek K, Sonne J, Ring-Larsen H,
Poulsen HE, Friis H, Bygum KH.
Viral load is a negative predictor of
antioxidant levels in hepatitis C
patients. Scand J Infect Dis
2005;37(9):686-9.
Klausen P, Niemann CU, Cowland JB,
Krabbe K, Borregaard N. On mouse
and man: neutrophil gelatinase
associated lipocalin is not involved in
apoptosis or acute response. Eur J
Haematol 2005;75(4):332-40.
Knudsen LM, Nielsen B, Gimsing P,
Geisler C. Autologous stem cell
transplantation in multiple myeloma:
outcome in patients with renal failure.
Eur J Haematol 2005;75(1):27-33.
Masmas TN, Madsen HO, Petersen SL,
Ryder LP, Svejgaard A, Alizadeh M,
et al. Evaluation and automation of
hematopoietic chimerism analysis
based on real-time quantitative
polymerase chain reaction. Biol
Blood Marrow Transplant
2005;11(7):558-66.
Moller T, Borregaard N, Tvede M,
Adamsen L. Patient education--a
strategy for prevention of infections
caused by permanent central venous
catheters in patients with
haematological malignancies: a
randomized clinical trial. J Hosp
Infect 2005;61(4):330-41.
Petersen SL, Sidorov IA, Russell CA,
Dickmeiss E, Vindelov LL. Limiting
dilution analysis of interleukin-2
producing helper T-cell frequencies
as a tool in allogeneic hematopoietic
cell transplantation. Transplantation
2005;80(5):573-81.
Sorensen OE, Borregaard N.
Cathelicidins--nature's attempt at
combinatorial chemistry. Comb
Chem High Throughput Screen
2005;8(3):273-80.
Theilgaard-Monch K, Jacobsen LC,
Rasmussen T, Niemann CU, Udby L,
Borup R, et al. Highly glycosylated
alpha1-acid glycoprotein is
synthesized in myelocytes, stored in
secondary granules, and released by
activated neutrophils. J Leukoc Biol
2005;78(2):462-70.
Theilgaard-Monch K, Jacobsen LC,
Borup R, Rasmussen T, Bjerregaard
MD, Nielsen FC, et al. The
transcriptional program of terminal
granulocytic differentiation. Blood
2005;105(4):1785-96.
Udby L, Lundwall A, Johnsen AH,
Fernlund P, Valtonen-Andre C, Blom
AM, et al. -Microseminoprotein
binds CRISP-3 in human seminal
plasma. Biochem Biophys Res
Commun 2005;333(2):555-61.
Udby L, Bjartell A, Malm J, Egesten A,
Lundwall A, Cowland JB, et al.
Characterization and localization of
cysteine-rich secretory protein 3
(CRISP-3) in the human male
reproductive tract. J Androl
2005;26(3):333-42.
B. Medforfatter fra forskningsenheden
Andersen J, Heilmann C, Jacobsen N,
Bendtzen K, Muller K. Cytokines and
soluble tumour necrosis factor I
receptor levels during pretransplant
conditioning in allogeneic stem-cell
transplantation. Int
Immunopharmacol 2005;5(1):67-71.
Andersen MH, Svane IM, Kvistborg P,
Nielsen OJ, Balslev E, Reker S, et al.
Immunogenicity of Bcl-2 in patients
with cancer. Blood 2005;105(2):728-
34.
Braendstrup P, Bjerrum OW, Nielsen OJ,
Jensen BA, Clausen NT, Hansen PB,
et al. Rituximab chimeric anti-CD20
monoclonal antibody treatment for
adult refractory idiopathic
Videnskabelig årsrapport 29