hand book for dental surgeons - Indian Dental Association ...

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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders
Normal haemostatic mechanism is disturbed when any defect occurs in the mechanism of primary haemostasis
for secondary haemostasis and it results in bleeding disorders. On this basis, bleeding disorders can be broadly
classified as due to primary haemostatic disorder or due to secondary haemostatic disorder or due to secondary
haemostatic disorder. Primary heamostatic (Platelet) disorders are further subdivided in two types non
thrombocytopenic purpura and thromobocytopenic purpura.
Non thrombocytopenic purpura is further subdivided into defects of platelet adhesion (Von Willebrandís
disease, Bernad soulier syndrome), defects of platelet aggregation (Glanzmannís Thrombosthenia), defects of
platelet release (drug induced granule storage pool defect, uremia, platelet coating by pencillin or paraproteins)
and defects of platelet coagulant activity (Scottís syndrome).
Secondary haemostatic (coagulation) disorders are further subdivided into two types inherited
(hemophilia A, hemophilia B, parahemophilia, etc. ) and acquired (liver disease, renal failure, DIC, anti-
coagulation drugs, vitamin deficiency)
The best method of determining whether the defect is in primary haemostasis or secondary haemostasis
is by various laboratory investigations. Most important screening tests of primary haemostatic system are
platelet count and bleeding time.
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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders