hand book for dental surgeons - Indian Dental Association ...

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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders
Genetics Of Hemophilia-Carrier Detection And Antental Diagnosis
The gene for factors VIII and IX are both located on the x-chromosome. Hemophilia is
therefore said to be an x-linked hereditary disorder. This results in males being affected by the disease
while females are carriers. While affected males with no functioning factor VII or IX gene have very
low to absent factors in the blood, carrier females have at least one (out of two) functioning X-
chromosomes with a normal factor VIII or IX gene that provides about 50% factor levels. Carrier
females who have excessive lyonization of the normal x-chromosome can have very low F VIII levels
and symptoms of bleeding.
Identification Of Carriers
A woman is a definite carrier if:
Her father has hemophilia
She has one son with hemophilia and a first degree relative (brother, uncle or other male
relative) who are affected.
She has two or more sons with hemophilia.
A Women Is A Possible Carrier If:
She has one or more maternal relatives with hemophilia
She has one son with hemophilia and no other affected relatives.
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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders