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Hand <strong>book</strong> <strong>for</strong> <strong>dental</strong> <strong>surgeons</strong> on <strong>dental</strong> management of persons with hemophilia and other haemostatic disorders<br />

Prophylaxis - A treatment regimen aimed at preventing bleeding episodes among people with hemophilia.<br />

Primary prophylaxis - A method of regularly scheduled treatments to prevent bleeding episodes be<strong>for</strong>e they<br />

occur. Today, the majority of people with severe hemophilia begin this regimen at a young age to prevent long-<br />

term damage to joints.<br />

Recombinant - A type of factor concentrate that is manufactured in a laboratory instead of being separated from<br />

human blood. Recombinant proteins are copies of certain kinds of proteins found in human blood plasma.<br />

Spontaneous bleeding - Bleeding that happens <strong>for</strong> no clear reason (not after an injury or surgery).<br />

Synovium - The lining of the joint capsule. It is made of special cells that make a slippery, oily fluid that helps<br />

the joint move easily.<br />

Spontaneous mutation - The development of a hereditary disease <strong>for</strong> which there is no family history.<br />

Target joint - A term <strong>for</strong> a particular joint that has experienced repeated bleeds or at least four bleeds into one<br />

joint within a six-month period.<br />

Thrombophilia - A categorical term <strong>for</strong> several distinct conditions where there is an increased tendency <strong>for</strong><br />

excessive clotting.<br />

Von Willebrand Disease - A bleeding disorder in which von Willebrand factor, a blood protein, is either<br />

missing or does not function properly. Von Willebrand disease is the most common bleeding disorder since<br />

both men and women can inherit it equally.<br />

Venepuncture - This can be done to take blood or to give an intravenous injection.<br />

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Hand <strong>book</strong> <strong>for</strong> <strong>dental</strong> <strong>surgeons</strong> on <strong>dental</strong> management of persons with hemophilia and other haemostatic disorders

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