hand book for dental surgeons - Indian Dental Association ...

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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders
In fresh plasma, the red cells have been removed, leaving the blood proteins including the clotting
factors. It is less effective than cryoprecipitate for the treatment of hemophilia A because the factor VIII is less
concentrated. Large volumes of plasma must be transfused. This can cause circulatory overload.
The life of the clotting factors is preserved by making a product called fresh frozen plasma (FFP). FFP
is still the only product available for treatment of hemophilia A and B in some countries.
There are considerable drawbacks to the use of whole blood in the treatment of hemophilia. First, it must
be fresh because the activity of the clotting factors in the drawn blood decreases quickly with time. second, the
red cells it contains must, of course, be compatible with those of the recipient. third, it takes a large volume of
whole blood to stop a bleed and this volume may overload the circulation and cause the heart to fail.
Antifibrinolytic medicines (including tranexamic acid and aminocaproic acid) may be used with
replacement therapy. Theyíre usually given as a pill, and they help keep blood clots from breaking down.
These medicines most often are used before dental work or to treat bleeding from the mouth or nose or mild
intestinal bleeding.
Researchers are trying to find ways to correct the faulty genes that cause hemophilia. Such gene therapy
hasnít yet developed to the point that itís an accepted treatment. But researchers continue to test gene therapies
for hemophilia in clinical trials.
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Hand book for dental surgeons on dental management of persons with hemophilia and other haemostatic disorders