hand book for dental surgeons - Indian Dental Association ...
hand book for dental surgeons - Indian Dental Association ...
hand book for dental surgeons - Indian Dental Association ...
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Hand <strong>book</strong> <strong>for</strong> <strong>dental</strong> <strong>surgeons</strong> on <strong>dental</strong> management of persons with hemophilia and other haemostatic disorders<br />
Among the various disorders of secondary hemostatisis most well known and common is haemophilia<br />
A. It has an incidence of 1 or 2/100000 of the population and it is caused by a deficiency of antihemophilic<br />
globulin (AHG or Factor 8) in the plasma. It is inherited as a sex-linked recessive character, appearing only in<br />
males and transmitted to them by clinically normal female carriers. The defective gene on the X chromosome<br />
causes a deficiency of Factor 8, Normal plasma contains one unit of a factor 8 per ml. or 100% level.<br />
Deficiency of factor is expressed as percentage (0.25unit/ml=25%). Patients with less than 1% AHG have<br />
severe disease. They bleed frequently into soft tissues, muscles and weight bearing joints even without<br />
discernible trauma. When level is between 1-5%, it indicates moderate disease and there are less severe<br />
bleeding episodes. Levels above 5% have mild disease in which there is infrequent bleeding usually secondary<br />
to trauma or surgery levels above 25% cause no troubles unless patient suffers from major trauma. Majority of<br />
patients have level of factor 8 less than 5%.<br />
The clotting time is not prolonged until the level of AHG falls below 1%. The only safe test is to<br />
estimate the AHG level in the patient <strong>for</strong> diagnosing the presence of this disease.<br />
Visit : http://image.idakunnamkulam.com/<br />
Hand <strong>book</strong> <strong>for</strong> <strong>dental</strong> <strong>surgeons</strong> on <strong>dental</strong> management of persons with hemophilia and other haemostatic disorders