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BY ANDREW DOUGLAS<br />
WITH ALL DUE RESPECT TO THE FAILED<br />
HALIFAX LIBERAL CANDIDATE, DR. STAN<br />
KUTCHER IS FULL OF SHIT.<br />
You might have heard that Dr. Stan successfully<br />
wrested an apology and retraction<br />
from the weekly freebie The Coast after<br />
it published a piece days before the<br />
election pointing out Dr. Stan’s involvement<br />
in an infamous study about the effectiveness<br />
of the antidepressant drug paroxetine<br />
in adolescents. The study, published in the<br />
Journal of the American Academy of<br />
Child and Adolescent Psychiatry in 2001,<br />
found that Paxil (the drug’s North American<br />
trade name) was “generally well tolerated<br />
and effective for major depression in<br />
adolescents.”<br />
In the piece, written by resident Coast<br />
muckraker Tim Bousquet, Dr. Stan is<br />
quoted as saying the study hasn’t caused<br />
“any particular controversy,” although there<br />
is “a group of people who would like to<br />
cause a controversy around it.”<br />
The truth is, controversy has dogged<br />
Paxil Study 329 for years.<br />
In 2004, a California law firm sued Paxil<br />
manufacturer/study sponsor Glaxo-<br />
SmithKline for using the study, among other<br />
things, to misrepresent the drug’s safety.<br />
Author Alison Bass, who was quoted in<br />
Tim’s article and has since been falsely<br />
pilloried as a Scientologist because of her<br />
views, wrote a book about the litigation<br />
called Side Effects: A Prosecutor, a<br />
Whistleblower, and a Bestselling Antidepressant<br />
on Trial.<br />
Rudderham Chernin Law Office solicitor<br />
Dwight Rudderham, a staunch member<br />
of Team Cecil, is a smart, capable guy,<br />
no doubt. But you could also argue that<br />
he’s political poison. Dwight, after all, infamously<br />
<strong>com</strong>plained to the N.S. Barrister’s<br />
Society about <strong>com</strong>ments CBRM<br />
Mayor John Morgan, a lawyer by trade,<br />
made to the CBC in 2008 about the political<br />
leanings of the province’s judges.<br />
The saga went on for two years before<br />
ELECTION 2011<br />
Paxil study at centre of Coast/<br />
Dr. Stan row was controversial<br />
Dr. Stan Kutcher<br />
In 2008, a joint Australian/American paper<br />
concluded that Paxil 329’s authors (including<br />
Brown University, Rhode Island<br />
psych professor Martin Keller, Dr. Stan and<br />
a handful of others) cherry-picked data to<br />
support their foregone conclusions.<br />
The paper, published in the International<br />
Journal of Risk & Safety in Medicine, entitled<br />
Clinical Trials and Drug Promotion:<br />
Selective Reporting of Study 329, says<br />
GSK documents — revealed as a result of<br />
CECIL, FROM PREVIOUS PAGE Mayor John, who won the last two elec-<br />
tions <strong>with</strong> more than 80 per cent of the<br />
popular vote, was finally exonerated.<br />
Now Dwight is the tainted one, the man<br />
who tried to take down the people’s beloved<br />
mayor.<br />
Instead of recognizing this, and urging<br />
him to work behind the scenes, Cecil<br />
made the mistake of putting Dwight front<br />
and centre. Every Thursday on Information<br />
Morning in Cape Breton throughout<br />
the campaign, Dwight was the Conservative<br />
voice on their political panel, remind-<br />
the litigation — state that “Study 329 was<br />
negative for efficacy on all eight protocol<br />
specified out<strong>com</strong>es and positive for harm.”<br />
Translation: Paxil, according to their research<br />
and for their purposes, wasn’t worth<br />
a damn.<br />
The paper finds that Keller and his coauthors<br />
“searched for other out<strong>com</strong>es that<br />
matched their beliefs about efficacy.” In<br />
other words, they had a pre-conceived<br />
notion about Paxil’s effectiveness, and<br />
went searching for data that supported it.<br />
According to the 2008 paper’s authors,<br />
such a technique is known as “data torturing.”<br />
“Confirmation bias could also lead authors<br />
who were unconcerned about adverse<br />
events (serious side effects among<br />
their human adolescent guinea pigs) to<br />
look less closely at that data and to attribute<br />
(such events) to non-drug causes<br />
such as ‘arguments <strong>with</strong> boyfriends.’”<br />
In defence of their methods, Keller has<br />
said that “they believed paroxetine was effective<br />
and therefore viewed the efficacy<br />
results as a false negative.”<br />
Incidentally, both Health Canada and the<br />
FDA, among other regulatory bodies<br />
around the world, re<strong>com</strong>mend against<br />
using Paxil to treat adolescent depression.<br />
Doesn’t sound controversial to me<br />
at all.<br />
An automated “out of office reply” was<br />
the only response to an email I sent to Dr.<br />
Stan’s office requesting <strong>com</strong>ment. His<br />
assistant didn’t return a phone message<br />
before press time.<br />
andrew@atlanticfrank.ca<br />
ing thousands of listeners that John<br />
Morgan’s mortal enemy wants them to vote<br />
for Cecil.<br />
So in the end, while Cecil and his crack<br />
campaign team are certainly wel<strong>com</strong>e to<br />
blame Frank Magazine for their loss, I submit<br />
that they need look no further than in<br />
the mirror. The proof, I believe, is that a<br />
campaign as shoddily run as theirs managed<br />
to <strong>com</strong>e <strong>with</strong>in 860 votes of taking<br />
the prize. Imagine what would’ve happened<br />
if they’d used a little elbow grease?<br />
andrew@atlanticfrank.ca<br />
MAY 24, 2011 FRANK MAGAZINE 5