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BY ANDREW DOUGLAS<br />

WITH ALL DUE RESPECT TO THE FAILED<br />

HALIFAX LIBERAL CANDIDATE, DR. STAN<br />

KUTCHER IS FULL OF SHIT.<br />

You might have heard that Dr. Stan successfully<br />

wrested an apology and retraction<br />

from the weekly freebie The Coast after<br />

it published a piece days before the<br />

election pointing out Dr. Stan’s involvement<br />

in an infamous study about the effectiveness<br />

of the antidepressant drug paroxetine<br />

in adolescents. The study, published in the<br />

Journal of the American Academy of<br />

Child and Adolescent Psychiatry in 2001,<br />

found that Paxil (the drug’s North American<br />

trade name) was “generally well tolerated<br />

and effective for major depression in<br />

adolescents.”<br />

In the piece, written by resident Coast<br />

muckraker Tim Bousquet, Dr. Stan is<br />

quoted as saying the study hasn’t caused<br />

“any particular controversy,” although there<br />

is “a group of people who would like to<br />

cause a controversy around it.”<br />

The truth is, controversy has dogged<br />

Paxil Study 329 for years.<br />

In 2004, a California law firm sued Paxil<br />

manufacturer/study sponsor Glaxo-<br />

SmithKline for using the study, among other<br />

things, to misrepresent the drug’s safety.<br />

Author Alison Bass, who was quoted in<br />

Tim’s article and has since been falsely<br />

pilloried as a Scientologist because of her<br />

views, wrote a book about the litigation<br />

called Side Effects: A Prosecutor, a<br />

Whistleblower, and a Bestselling Antidepressant<br />

on Trial.<br />

Rudderham Chernin Law Office solicitor<br />

Dwight Rudderham, a staunch member<br />

of Team Cecil, is a smart, capable guy,<br />

no doubt. But you could also argue that<br />

he’s political poison. Dwight, after all, infamously<br />

<strong>com</strong>plained to the N.S. Barrister’s<br />

Society about <strong>com</strong>ments CBRM<br />

Mayor John Morgan, a lawyer by trade,<br />

made to the CBC in 2008 about the political<br />

leanings of the province’s judges.<br />

The saga went on for two years before<br />

ELECTION 2011<br />

Paxil study at centre of Coast/<br />

Dr. Stan row was controversial<br />

Dr. Stan Kutcher<br />

In 2008, a joint Australian/American paper<br />

concluded that Paxil 329’s authors (including<br />

Brown University, Rhode Island<br />

psych professor Martin Keller, Dr. Stan and<br />

a handful of others) cherry-picked data to<br />

support their foregone conclusions.<br />

The paper, published in the International<br />

Journal of Risk & Safety in Medicine, entitled<br />

Clinical Trials and Drug Promotion:<br />

Selective Reporting of Study 329, says<br />

GSK documents — revealed as a result of<br />

CECIL, FROM PREVIOUS PAGE Mayor John, who won the last two elec-<br />

tions <strong>with</strong> more than 80 per cent of the<br />

popular vote, was finally exonerated.<br />

Now Dwight is the tainted one, the man<br />

who tried to take down the people’s beloved<br />

mayor.<br />

Instead of recognizing this, and urging<br />

him to work behind the scenes, Cecil<br />

made the mistake of putting Dwight front<br />

and centre. Every Thursday on Information<br />

Morning in Cape Breton throughout<br />

the campaign, Dwight was the Conservative<br />

voice on their political panel, remind-<br />

the litigation — state that “Study 329 was<br />

negative for efficacy on all eight protocol<br />

specified out<strong>com</strong>es and positive for harm.”<br />

Translation: Paxil, according to their research<br />

and for their purposes, wasn’t worth<br />

a damn.<br />

The paper finds that Keller and his coauthors<br />

“searched for other out<strong>com</strong>es that<br />

matched their beliefs about efficacy.” In<br />

other words, they had a pre-conceived<br />

notion about Paxil’s effectiveness, and<br />

went searching for data that supported it.<br />

According to the 2008 paper’s authors,<br />

such a technique is known as “data torturing.”<br />

“Confirmation bias could also lead authors<br />

who were unconcerned about adverse<br />

events (serious side effects among<br />

their human adolescent guinea pigs) to<br />

look less closely at that data and to attribute<br />

(such events) to non-drug causes<br />

such as ‘arguments <strong>with</strong> boyfriends.’”<br />

In defence of their methods, Keller has<br />

said that “they believed paroxetine was effective<br />

and therefore viewed the efficacy<br />

results as a false negative.”<br />

Incidentally, both Health Canada and the<br />

FDA, among other regulatory bodies<br />

around the world, re<strong>com</strong>mend against<br />

using Paxil to treat adolescent depression.<br />

Doesn’t sound controversial to me<br />

at all.<br />

An automated “out of office reply” was<br />

the only response to an email I sent to Dr.<br />

Stan’s office requesting <strong>com</strong>ment. His<br />

assistant didn’t return a phone message<br />

before press time.<br />

andrew@atlanticfrank.ca<br />

ing thousands of listeners that John<br />

Morgan’s mortal enemy wants them to vote<br />

for Cecil.<br />

So in the end, while Cecil and his crack<br />

campaign team are certainly wel<strong>com</strong>e to<br />

blame Frank Magazine for their loss, I submit<br />

that they need look no further than in<br />

the mirror. The proof, I believe, is that a<br />

campaign as shoddily run as theirs managed<br />

to <strong>com</strong>e <strong>with</strong>in 860 votes of taking<br />

the prize. Imagine what would’ve happened<br />

if they’d used a little elbow grease?<br />

andrew@atlanticfrank.ca<br />

MAY 24, 2011 FRANK MAGAZINE 5

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