Full Journal - Journal of Cell and Molecular Biology - Haliç Üniversitesi

Journal of Cell and Molecular Biology 1: 81-85, 2002.
Golden Horn University, Printed in Turkey.
Effect of epirubicin and tamoxifen on labelling index in FM3A cells
Mehmet Topçul 1 *, Gül Özcan Ar›can 1 , Nevin Erensoy 2 , Atilla Özalpan 3
1 University of ‹stanbul, Faculty of Science, Department of Biology, 34459, Vezneciler, ‹stanbul, Turkey;
2 University of ‹stanbul, Faculty of Cerrahpafla Medicine, Department of Medical Biology, ‹stanbul, Turkey;
3 University of Golden Horn, Faculty of Arts and Sciences, Department of Molecular Biology and
Genetics, 34280, ‹stanbul, Turkey (* author for correspondence)
Received 15 April 2002; Accepted 21 June 2002
Abstract
C3H mouse mammary carsinoma-derived FM3A cell line grown in RPMI 1640+10%FBS medium as suspension
culture have been used in tissue culture studies in recent years. Changes in labelling index were examined in the
present study, applying in vitro doses of epirubicin, tamoxifen and epirubicin+tamoxifen to FM3A cells. The
findings reveal that treatments of epirubicin and tamoxifen lower the percentage of the cells at S phase, while
combined treatment of epirubicin and tamoxifen gives more successful results, being statistically significant
(p