AA. Gastric C I 06. ppt - Università degli studi di Pavia

GASTRIC ADENOCARCINOMA
Etiology. II. Bacteria and favoring growth factors
* exogenous bacteria (= partially decayed foods,
especially consumed by lower socioeconomic classes);
- endogenous bacteria (such as Helicobacter pylori),
whose growth results from loss of gastric acidity:
* favoring factors:
- partial gastrectomy to control benign peptic ulcer
disease (15 - 20 yrs earlier) abolishes acid - producing cells
of gastric antrum;
- achlorhydria, atrophic gastritis and pernicious anemia
(= precancerous situations) in elderly (in pts with atrophic
gastritis, usual gastric mucosa replaced by intestinal - type
cells → intestinal metaplasia → cellular atypia and
eventual neoplasia)