AA. Gastric C I 06. ppt - Università degli studi di Pavia

GASTRIC ADENOCARCINOMA
Genetics. II.
* multiple genetic and epigenetic alterations
in oncogenes, tumour - suppressor genes, cell -
cycle regulators, cell adhesion molecules, DNA
repair genes, genetic instability and telomerase
activation implicated in multistep process of
human stomach carcinogenesis;
- combinations of alterations # in two
histological types of GC → distinct
carcinogenetic pathways in well - differentiated
(intestinal - type GC) and poorly differentiated
(diffuse - type GC)