AA. Gastric C I 06. ppt - Università degli studi di Pavia

Early diffuse gastric cancers
from prophylactic - gastrectomy
specimens
A) superficial infiltrate of signet - ring
carcinoma cells (EE staining);
B) immunohistochemistry with Abs to
type IV collagen = invasive nature of
signet - cell infiltrates (thick
basement membrane under surface
epithelium and around both glands and
capillaries stains strongly; no distinct
staining around signet - ring cells);
C) signet - ring - cells infiltrate in
superficial lamina propria in gastric
cardia (PAS with diastase staining for
mucina);
D) epithelial nature of infiltrate
(immunohistochemistry for cytokeratin);
E) in situ signet - ring - cell lesions in
gastric cardia;
F, G, H) early diffuse gastric cancers
(EE)