AA. Gastric C I 06. ppt - Università degli studi di Pavia
AA. Gastric C I 06. ppt - Università degli studi di Pavia
AA. Gastric C I 06. ppt - Università degli studi di Pavia
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GASTRIC ADENOCARCINOMA<br />
Genetics. III. Intestinal - type GC<br />
* in multistep process of intestinal - type<br />
carcinogenesis, genetic pathway <strong>di</strong>vided into 3<br />
subpathways:<br />
- intestinal metaplasia → adenoma →<br />
carcinoma;<br />
- intestinal metaplasia → carcinoma, and<br />
- de novo;<br />
* infection with HP is a strong trigger for<br />
hyperplasia of hTERT+ (human telomerase reverse<br />
transcriptase, regulating human telomers and<br />
senescence) “stem cells” in intestinal metaplasia
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