AA. Gastric C I 06. ppt - Università degli studi di Pavia

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FAMILY WITH PREDICTIVE GENETIC - TESTING (A) AND SEQUENCE CHROMATOGRAM OF CDH1 (EXON 12) (B) A) squares = male and circles = female members; - = unaffected and = affected persons; - slash = death and line under symbol = prophylactic gastrectomy; - + sign = mutation+, - sign = mutation-, in parentheses = result of predictive testing; - arrow identifies proband [age at diagnosis and death (in parentheses) under each symbol]; B) codon 598 in yellow; - pt IV - 2 = wild - type sequence and pt IV - 1 = heterozygous for C2095T mutation; [- Opa = opal nonsense mutation (one of 3 nonsense codons predicting protein truncation) (NL = normal sequence and Mut = mutation; N in nucleotide chromatogram indicates that both C and T are present)]
GASTRIC ADENOCARCINOMA Genetics. VIII. * from prophylactic gastrectomy in pts to regular endoscopic surveillance with multiple random biopsies → presence of microscopic intrahepitelial carcinomas → early total gastrectomy for this small pt’s population (lack of other effective early tumor detection with less aggressive approaches)
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Università degli Studi di Pavia AA
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GASTRIC ADENOCARCINOMA
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GASTRIC ADENOCARCINOMA (Cancer Stat
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* age - adjusted cancer death rates
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RISK FACTORS AND PATHOGENESIS
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GASTRIC ADENOCARCINOMA Etiology. I.
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GASTRIC ADENOCARCINOMA Etiology. II
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NATURAL HISTORY OF HELICOBACTER PYL
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NATURAL HISTORY OF HELICOBACTER PYL
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Pathogen - host interactions in pat
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Pathogen - host interactions in pat
Page 23 and 24: GASTRIC ADENOCARCINOMA Etiology. II
Page 25 and 26: GASTRIC CANCER Pathology. I. * 85%
Page 27 and 28: GASTRIC CANCER Pathology. III. Leio
Page 30 and 31: GASTRIC ADENOCARCINOMA Pathology. V
Page 32 and 33: GASTRIC ADENOCARCINOMA Pathology. V
Page 34 and 35: GASTRIC ADENOCARCINOMA Pathology. I
Page 37 and 38: GASTRIC ADENOCARCINOMA Pathology. X
Page 47 and 48: “EARLY” GASTRIC CANCER
Page 55 and 56: GENETICS
Page 57 and 58: GASTRIC ADENOCARCINOMA Genetics. II
Page 59 and 60: GENETIC STEPS OF INTESTINAL TYPE GA
Page 61 and 62: GASTRIC ADENOCARCINOMA Genetics. II
Page 63 and 64: Schematic structure of telomere - r
Page 65 and 66: * adenoma → carcinoma sequence in
Page 67 and 68: GASTRIC ADENOCARCINOMA Genetics. VI
Page 69 and 70: GASTRIC ADENOCARCINOMA Genetics. VI
Page 71 and 72: RECEPTOR TYROSINE KINASE AND PROLIF
Page 73: SCHEMA TO GUIDE THE MANAGEMENT OF F
Page 77 and 78: CLINICAL FEATURES
Page 79 and 80: GASTRIC ADENOCARCINOMA Clinical fea
Page 81 and 82: GASTRIC ADENOCARCINOMA Clinical fea
Page 83: GASTRIC ADENOCARCINOMA Clinical fea
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AA. Gastric C I 06. ppt - Università degli studi di Pavia

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