AA. Gastric C I 06. ppt - Università degli studi di Pavia

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NATURAL HISTORY OF HELICOBACTER PYLORI INFECTION. II. * most HP strains (= type I; e.g. strain 26695) causing disease contain cag (= cytotoxin - associated Ag) chromosomal pathogenicity island (~ 37,000 bp and 29 genes); - cag island splits into 2 parts, with most cag arranged genes involved in secretory machinery translocating protein CagA (cytotoxin - associated Ag A) into cytoplasm of gastric epithelial cells; * most genes involved in 2 major processes: - translocation of CagA from bacterium to host cell - production of IL - 8 (chemotactic for neutrophils and lymphocytes and angiogenic) by gastric cells
NATURAL HISTORY OF HELICOBACTER PYLORI INFECTION. III. * HP usually acquired in childhood; * acute HP infection (gray) → transient, rarely diagnosed hypo - chlorhydria; - persistent infection → chronic gastritis (green) in most pts (80 - 90%, without symptoms); * variable further clinical course: hypocloridria - pts with ↑ acid output (red) → antral gastritis predisposing to duodenal ulcer; - pts with ↓ acid output (black) → gastritis in stomach’s body predisposing to gastric ulcer and (more rarely) to gastric carcinoma; [* HP infection induces mucosa - associated lymphoid tissue (MALT), possibly leading to malignant lymphoma]
Page 1 and 2: Università degli Studi di Pavia AA
Page 3 and 4: GASTRIC ADENOCARCINOMA
Page 5 and 6: GASTRIC ADENOCARCINOMA (Cancer Stat
Page 7 and 8: * age - adjusted cancer death rates
Page 9 and 10: RISK FACTORS AND PATHOGENESIS
Page 11 and 12: GASTRIC ADENOCARCINOMA Etiology. I.
Page 13 and 14: GASTRIC ADENOCARCINOMA Etiology. II
Page 15: NATURAL HISTORY OF HELICOBACTER PYL
Page 19 and 20: Pathogen - host interactions in pat
Page 21 and 22: Pathogen - host interactions in pat
Page 23 and 24: GASTRIC ADENOCARCINOMA Etiology. II
Page 25 and 26: GASTRIC CANCER Pathology. I. * 85%
Page 27 and 28: GASTRIC CANCER Pathology. III. Leio
Page 30 and 31: GASTRIC ADENOCARCINOMA Pathology. V
Page 32 and 33: GASTRIC ADENOCARCINOMA Pathology. V
Page 34 and 35: GASTRIC ADENOCARCINOMA Pathology. I
Page 37 and 38: GASTRIC ADENOCARCINOMA Pathology. X
Page 47 and 48: “EARLY” GASTRIC CANCER
Page 55 and 56: GENETICS
Page 57 and 58: GASTRIC ADENOCARCINOMA Genetics. II
Page 59 and 60: GENETIC STEPS OF INTESTINAL TYPE GA
Page 61 and 62: GASTRIC ADENOCARCINOMA Genetics. II
Page 63 and 64: Schematic structure of telomere - r
Page 65 and 66: * adenoma → carcinoma sequence in
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GASTRIC ADENOCARCINOMA Genetics. VI
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RECEPTOR TYROSINE KINASE AND PROLIF
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SCHEMA TO GUIDE THE MANAGEMENT OF F
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CLINICAL FEATURES
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GASTRIC ADENOCARCINOMA Clinical fea
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AA. Gastric C I 06. ppt - Università degli studi di Pavia

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