AA. Gastric C I 06. ppt - Università degli studi di Pavia

Pathogen - host interactions in
pathogenesis of HP Infection. III.
* macrophages participating in IL -
8 production → proinflammatory
cytokines involved in activation of
recruited cells [especially T helper
cells (Th0, Th1, Th2), that respond
with a biased Th1 response to HP;
- in turn, Th1 - type cytokines such
as interferon - γ (INF - γ) →
expression of class II major
histocompatibility complexes
(MHC) and accessory molecules B7
- 1 and B7 - 2 by epithelial cells →
epithelial cells competent for
antigen presentation