Report in English with a Dutch summary (KCE reports 63A)
Report in English with a Dutch summary (KCE reports 63A)
Report in English with a Dutch summary (KCE reports 63A)
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<strong>KCE</strong> <strong>reports</strong> 63 Breast Cancer 93<br />
Study ID Ref Search<br />
date<br />
Tamoxifen 2y vs. 5y<br />
Nordenskjöld B<br />
2005<br />
Population Intervention Ouctomes Results Comments Study<br />
type<br />
years or over <strong>with</strong><br />
operable breast<br />
cancer (T1 T2 T3a,<br />
N0 N1a N1b, M0)<br />
[206] NA Postmenopausal<br />
women (less then 75<br />
years) <strong>with</strong> early<br />
stage breast cancer<br />
Belfiglio M 2005 [207] NA Women <strong>with</strong> breast<br />
carc<strong>in</strong>oma T1-3, N0-<br />
3, M0, aged 50-70<br />
years<br />
Tada K 2004 [208] NA Postmenopausal<br />
patients <strong>with</strong> ER+<br />
breast cancer<br />
Tamoxifen vs. other SERM<br />
Pagani O 2004 [209] NA Post- and<br />
perimenopausal<br />
women <strong>with</strong> N+,<br />
ER+ breast cancer<br />
who were<br />
considered suitable<br />
for endocr<strong>in</strong>e<br />
therapy alone<br />
Johnston S 2004 [210] NA Postmenopausal<br />
patients <strong>with</strong><br />
progressive locally<br />
advanced/ metastatic<br />
breast cancer who<br />
had previously<br />
(MRM) (n=82) vs. tamoxifen<br />
(TAM) (n=82)<br />
Tamoxifen 20 mg/d for 2 years<br />
(n = 2129) vs. 5 years (n =<br />
2046)<br />
2 years vs. 5 years of<br />
Tamoxifen therapy<br />
Tamoxifen 20 mg/d for 2 years<br />
(n = 130) vs. 5 years (n = 126)<br />
Toremifene (n = 525) vs.<br />
tamoxifen (n = 510)<br />
Tamoxifen 40 mg (n = 26) vs.<br />
Idoxifene (n = 30)<br />
outcome: survival Significantly decreased time to progression<br />
<strong>in</strong> the TAM only group (logrank P
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