Report in English with a Dutch summary (KCE reports 63A)

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146 Breast Cancer KCE reports 63
N1 Metastasis in movable ipsilateral axillary lymph node(s)
N2 Metastasis in fixed ipsilateral axillary lymph node(s) or in clinically apparent* ipsilateral
internal mammary lymph nodes(s) in the absence of clinically evident axillary lymph node
metastases
- N2a metastasis in axillary lymph node(s) fixed to one another or to other
structures
- N2b metastasis only in clinically apparent* ipsilateral internal mammary
lymph nodes(s) in the absence of clinically evident axillary lymph node
metastases
N3 Metastasis in ipsilateral infraclavicular lymph node(s) with or without axillary lymph node
involvement; or in clinically apparent* ipsilateral internal mammary axillary lymph node
metastasis; or metastasis in ipsilateral supraclavicular lymph node(s) with or without
axillary or internal mammary lymph node involvement
- N3a metastasis in infraclavicular lymph node(s)
- N3b metastasis in internal mammary and axillary lymph nodes
- N3c metastasis in supraclavicular lymph node(s)
*clinically apparent = detected by clinical examination or by imaging studies excluding
lymphoscintigraphy
M- Distant metastasis
Mx Distant metastasis cannot be assessed
M0 No distant metastasis
M1 Distant metastasis
pTNM
pT: corresponds to cT categories, but there may not be gross tumor at the margins of
resection. Only the invasive component counts (not in situ).
pM: corresponds to cM categories.
pN: at least level I should have been resected to allow evaluation (generally 6 or more lymph
nodes). If classification is based only on sentinel node biopsy without subsequent axillary
lymph node dissection, it should be designated with (sn).
- pNx: regional lymph nodes cannot be assessed (e.g. previously removed, or
not removed for pathologic study)
- pN0: no regional lymph node metastasis.
Cases with isolated tumor cells in regional lymph nodes are classified as pN0.
Isolated tumor cells are single tumor cells or small clusters of cells, not more than
0.2 mm in greatest dimension, that are usually detected by immunohistochemistry or
molecular methods but which may be verified on HeE stains. Isolated tumor cells do
not typically show evidence of metastatic activity, e.g., proliferation of stromal
reaction.
- pN1mi: micrometastasis (larger than 0.2 mm, but none larger than 2 mm in
greatest dimension)
- pN1: metastasis in 1-3 ipsilateral axillary lymph node(s), and/or in ipsilateral
internal mammary nodes with microscopic metastasis detected by sentinel lymph
node dissection but not clinically apparent*
o pN1a metastasis in 1-3 axillary lymph node(s), including at least one
larger than 2 mm in greatest diameter.