Report in English with a Dutch summary (KCE reports 63A)
Report in English with a Dutch summary (KCE reports 63A)
Report in English with a Dutch summary (KCE reports 63A)
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<strong>KCE</strong> <strong>reports</strong> 63 Breast Cancer 65<br />
Study ID Ref Search<br />
date<br />
Stag<strong>in</strong>g of breast cancer <strong>with</strong> sent<strong>in</strong>el biopsy.<br />
X<strong>in</strong>g Y et al [50] 2004 Women <strong>with</strong><br />
operable breast<br />
cancer, hav<strong>in</strong>g<br />
undergone<br />
preoperative<br />
Population Intervention Outcomes Results Comments Study<br />
type<br />
chemotherapy<br />
Mansel R 2006 [51] NA Women <strong>with</strong><br />
early-stage<br />
cl<strong>in</strong>ically nodenegative<br />
breast<br />
cancer<br />
SLNB<br />
Standard: axillary node<br />
dissection<br />
SLNB (n = 478) vs. standard<br />
axillary treatment (n = 476)<br />
If positive node on SLNB:<br />
axillary lymph node dissection<br />
or axillary RT<br />
MeSH term(s) used: Breast Neoplasms, Sent<strong>in</strong>el Lymph Node Biopsy.<br />
Arm morbidity<br />
Quality of life<br />
Sensitivity: 67 – 100% (pooled estimate<br />
88%, 95%CI 85-90)<br />
Lymphedema at 12 mo: RR 0.37 (95%CI<br />
0.23-0.60) <strong>in</strong> favour of SLNB<br />
Sensory loss at 12 mo: RR 0.37 (95%CI<br />
0.27-0.50) <strong>in</strong> favour of SLNB<br />
Quality of life: statistically significantly<br />
better for SLNB group<br />
21 cohort studies <strong>in</strong>cluded<br />
(total of 1273 patients)<br />
Level of<br />
evidence<br />
SR Moderate<br />
RCT High
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