Report in English with a Dutch summary (KCE reports 63A)

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2 Breast Cancer KCE reports 63 SR Systematic review TPA Tissue polypeptide antigen TPS Tissue polypeptide specific antigen US Ultrasonography
KCE reports 63 Breast Cancer 3 Table of contents Scientific summary 1 INTRODUCTION............................................................................................. 5 2 METHODOLOGY............................................................................................. 6 2.1 GENERAL APPROACH................................................................................................................6 2.2 CLINICAL QUESTIONS ..............................................................................................................6 2.3 SEARCH FOR EVIDENCE ...........................................................................................................7 2.3.1 Clinical practice guidelines................................................................................................7 2.3.2 Additional evidence............................................................................................................9 2.4 QUALITY APPRAISAL..................................................................................................................9 2.4.1 Clinical practice guidelines................................................................................................9 2.4.2 Additional evidence............................................................................................................9 2.5 DATA EXTRACTION AND SUMMARY ................................................................................9 2.6 FORMULATION OF RECOMMENDATIONS.......................................................................9 2.7 EXTERNAL REVIEW.....................................................................................................................9 3 FINAL RECOMMENDATIONS..................................................................... 11 3.1 GENERAL ALGORITHM .......................................................................................................... 11 3.2 POPULATION SCREENING ................................................................................................... 12 3.3 MANAGEMENT OF HIGH-RISK WOMEN......................................................................... 13 3.3.1 Definition of high-risk ..................................................................................................... 13 3.3.2 Breast cancer susceptibility gene testing.................................................................... 13 3.3.3 Surveillance of women with a high risk for developing breast cancer................ 14 3.3.4 Treatment of women with a high risk for developing breast cancer.................. 14 3.4 DIAGNOSIS OF BREAST CANCER ...................................................................................... 17 3.4.1 Triple assessment ............................................................................................................ 17 3.4.2 Magnetic resonance imaging (MRI).............................................................................. 18 3.4.3 99mTc-MIBI scintimammography (SMM)................................................................... 18 3.5 STAGING OF BREAST CANCER .......................................................................................... 19 3.5.1 Routine staging tests ....................................................................................................... 19 3.5.2 Tumour markers.............................................................................................................. 19
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KCE reports 1. Effectiviteit en kos
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Report in English with a Dutch summary (KCE reports 63A)

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