Report in English with a Dutch summary (KCE reports 63A)

KCE reports 63 Breast Cancer 75
Study ID Ref Search
date
Martelli G 2005 [170] NA Women, 65 to
80 years of age,
with early
breast cancer
(T ≤2 cm) and
Population Intervention Outcomes Results Comments Study
type
cN0
Tominaga T 2004 [171] NA Stage II breast
cancer (T2 N0
or T2 N1a)
(n=1209)
Louis-Sylvestre C
2004
[78] NA Patients with a
breast
carcinoma less
than 3 cm in
diameter and
N0M0 (n=658)
Conservative breast
surgery with(n = 109)
or without axillary
dissection (n = 110)
Level II (n = 604) vs.
level III axillary node
dissection (n = 605)
Lumpectomy plus
axillary radiotherapy (n
= 332) versus
lumpectomy plus
axillary dissection (n =
326)
MeSH term(s) used: Breast Neoplasms, Lymphatic Metastasis.
Axillary events
Overall mortality
Breast cancer mortality
Breast events
Survival
Disease-free survival
Survival
Axillary events
No significant differences in overall or
breast cancer mortality, or crude
cumulative incidence of breast events
10-year cumulative survival rate: 86.6%
after level II vs. 85.7% after level III
axillary dissection (HR 1.02; P = 0.931,
log rank test)
10-year disease-free survival rate: 73.3%
vs. 77.8% respectively (HR 0.94, P =
0.666)
Overall survival and disease-free survival
rates in the two groups were similar after
both procedures
Increased survival rate in the axillary
dissection group at 5 years (p=0.009), but
not at 10 and 15 years (73.8% v 75.5% at
15 years).
Recurrences in the axillary node were
less frequent in the axillary dissection
group at 15 years (1% v 3%; p=0.04).
There was no difference in recurrence
rates in the breast or supraclavicular and
distant metastases between the two
groups.
RCT High
RCT High
RCT High
Level of
evidence