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In the analysis of the readmission indicator patients who never had an admission of more<br />

than 24 hours were excluded. In the analysis of excess LOS only admissions of more<br />

than 24 hours were included.<br />

As effect modification between age and migrant groups was present we performed all<br />

analyses in two strata, notably patients younger than 45 years and patients of 45 years<br />

and older.<br />

To assess differences in the incidence of readmission within 30 days after a prior<br />

admission, we used stepwise multilevel logistic regression analysis. In the first model<br />

only migrant group and demographics (i.e. age and sex) were taken into account. In the<br />

second model we adjusted for potential confounding by patient mix by adding diagnosis,<br />

comorbidity and principal intervention. In the third model we examined the contribution<br />

of socio-economic indicators to the observed ethnic disparities. The associations between<br />

these factors and the incidence of readmissions within 30 days were assessed by odds<br />

ratios with 95% confidence intervals.<br />

Analogously, a stepwise multivariable logistic regression analysis was applied to assess<br />

disparities in excess LOS between migrant groups, while adjusting for confounding by<br />

patient-mix and finally for socio-economic indicators.<br />

The data in this study were hierarchical: admissions (level 1) are nested within hospitals<br />

(level 2). In a sensitivity analysis we assessed differences in the incidence of readmission<br />

within 30 days after a prior admission and excess LOS using stepwise multivariable<br />

multilevel logistic regression analysis, in which variation in readmission rate was<br />

apportioned to the admission, and hospital level (32,33). Based on the total variance,<br />

intra class correlations (ICCs) were calculated, which give an indication of the extent of<br />

the variance. For example, a high ICC at the hospital level, means that there is more<br />

homogeneity (low variation) within hospitals (patient are treated alike in a hospital), but<br />

high variation between hospitals.<br />

Results<br />

In total 1177,304 admissions from 433,501 patients in 139 hospitals locations were<br />

included in our sample. About 95 % were native Dutch and 5% were from non-OECD<br />

migrant groups. Most migrants were from the first generation, varying from 49% in<br />

Moroccan to 79% in Surinamese patients. Patients from migrant groups were younger<br />

and suffered less often from diseases of the heart, diseases of the arteries and<br />

neoplasms than their Dutch counterparts (Table 1).<br />

After 73,938 (6.3%) clinical admissions a clinical readmission occurred within 30 days<br />

after prior admission. Mean excess LOS of at least 3 days was present in 143,302<br />

(17.5%) admissions.<br />

The risk of readmission within 30 days after the initial admission is presented in table 2a<br />

and 2b for patients younger and older than 45 years of age respectively. In patient<br />

younger than 45 years, without adjustment for patient mix and socio-economic factors,<br />

the risk for readmission within 30 days is higher among Surinamese and Antillean<br />

patients and lower in Turkish patients compared to Dutch patients. After adjustment for<br />

patient-mix the odds ratios became closer to zero but the differences for all three<br />

migrant groups stayed statistically significant. After further adjustment for socioeconomic<br />

factors the differences between migrant groups and Dutch patients slightly decreased.<br />

In patients older than 45 years the risk of readmission within 30 days was higher in<br />

Turkish, Surinamese and Antillean patients than in Dutch patients (model 1). After<br />

adjustment for patient-mix the odds ratios remained stable but became borderline<br />

significant for Surinamese patients. After further adjustment for socioeconomic factors<br />

the differences between Turkish and Surinamese patients compared to Dutch patients<br />

decreased. However, Antillean patients still had a 14% readmission rate within 30 days<br />

than Dutch patients, which were not accounted for by socio-economic status.<br />

38

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