Immunotherapy Safety for the Primary Care ... - U.S. Coast Guard

Allergen immunotherapy: A practice parameter
second update
Supplement Editor: Linda Cox, MD
Co-editors: James T. Li, MD, Harold Nelson, MD, and Richard Lockey, MD
These parameters were developed by the Joint Task Force on
Practice Parameters, representing the American Academy of
Allergy, Asthma and Immunology; the American College of Allergy,
Asthma and Immunology; and the Joint Council of Allergy, Asthma
and Immunology.
The American Academy of Allergy, Asthma and Immunology
(AAAAI) and the American College of Allergy, Asthma and
Immunology (ACAAI) have jointly accepted responsibility for
establishing the ‘‘Allergen immunotherapy: a practice parameter
second update.’’ This is a complete and comprehensive document at
the current time. The medical environment is a changing
environment, and not all recommendations will be appropriate for
all patients. Because this document incorporated the efforts of
many participants, no single individual, including those who served
on the Joint Task Force, is authorized to provide an official AAAAI
or ACAAI interpretation of these practice parameters. Any request
for information about or an interpretation of these practice
Disclosure of potential conflict of interest: L. Cox has consulting arrangements
with Allergy Therapeutics, Genentech/Novartis, and Greer Laboratories and
is on the speakers’ bureau for Genentech/Novartis, GlaxoSmithKline, and
AstraZeneca. R. Lockey has received grant support from Greer Laboratories;
served as chairman of an advisory committee for ALK-Abelló for over
7 years; and has served as an expert witness for allergen immunotherapy
death for both plaintiff and defendant. H. Nelson has consulting arrangements
with Genentech/Novartis, Curalogic, GlaxoSmithKline, Inflazyme
Pharmaceuticals, Dey Laboratories, Dynavax Technologies, Altana, and
Schering-Plough; has received grant support from Dey Laboratories,
IVAX, MediciNova, Wyeth, Sepracor, Genentech, Schering-Plough, Novartis,
AstraZeneca, SkyPharma, Altana, and Roche; and is on the speakers’
bureau for GlaxoSmithKline and AstraZeneca. D. Bernstein has consulting
arrangements with ALK-Abelló and has received grant support from
Dynavax and ALK-Abelló. J. Blessing-Moore has received grant support
from Novartis-Genentech and AstraZeneca and is on the speakers’ bureau
for Schering-Plough, Merck, Aventis, Novartis/Genentech, AstraZeneca.
D. M. Lang has consulting arrangements with, has received grant support
from, and is on the speakers’ bureau for GlaxoSmithKline, Merck, Astra-
Zeneca, Centocor, Sanofi-Aventis, Schering-Plough, Verus, and Dey. J.
Oppenheimer has consulting arrangements with GlaxoSmithKline, Astra-
Zeneca, Sepracor, and Merck; has received grant support from AstraZeneca,
Sepracor, and Merck, Boehringer Ingelheim, Novartis/Genentech, and
Schering-Plough; and is on the speakers’ bureau for GlaxoSmithKline,
AstraZeneca, Sepracor, and Merck. J. M. Portnoy has consulting arrangements
with Greer and GlaxoSmithKline; has received grant support from
Clorox; and is on the speakers’ bureau for Schering-Plough, Merck, Aventis,
Secpracor, and AstraZeneca. S. A. Tilles has consulting arrangements with
Genentech, Schering-Plough, and GlaxoSmithKline; has received grant support
from AstraZeneca, Novartis, Medpoint, Apieron, and ALK-Abelló; and
is on the speakers’ bureau for GlaxoSmithKline, Pfizer, Genentech, and
Alcon. The rest of the authors have declared that they have no conflict of
interest.
Reprint requests: Joint Council of Allergy, Asthma and Immunology, 50 N
Brockway St, #3-3, Palatine, IL 60067.
J Allergy Clin Immunol 2007;120:S25-85.
0091-6749/$32.00
Ó 2007 American Academy of Allergy, Asthma & Immunology
doi:10.1016/j.jaci.2007.06.019
parameters by the AAAAI or the ACAAI should be directed to the
Executive Offices of the AAAAI, the ACAAI, and the Joint Council
of Allergy, Asthma and Immunology. These parameters are not
designed for use by pharmaceutical companies in drug promotion.
Published practice parameters of the Joint Task Force
on Practice Parameters for Allergy and Immunology
include the following:
1. Practice parameters for the diagnosis and treatment
of asthma. J Allergy Clin Immunol 1995;96(suppl):
S707-S870.
2. Practice parameters for allergy diagnostic testing.
Ann Allergy 1995;75:543-625.
3. Practice parameters for the diagnosis and management
of immunodeficiency. Ann Allergy 1996;76:282-94.
4. Practice parameters for allergen immunotherapy.
J Allergy Clin Immunol 1996;98:1001-11.
5. Disease management of atopic dermatitis: a practice
parameter. Ann Allergy 1997;79:197-211.
6. The diagnosis and management of anaphylaxis.
J Allergy Clin Immunol 1998;101(suppl):S465-S528.
7. Algorithm for the diagnosis and management of
asthma: a practice parameter update. Ann Allergy
1998;81:415-20.
8. Diagnosis and management of rhinitis: parameter
documents of the Joint Task Force on Practice
parameters in Allergy, Asthma and Immunology.
Ann Allergy 1998;81(suppl):S463-S518.
9. Parameters for the diagnosis and management of
sinusitis. J Allergy Clin Immunol 1998;102(suppl):
S107-S144.
10. Stinging insect hypersensitivity: a practice parameter.
J Allergy Clin Immunol 1999;103:963-80.
11. Disease management of drug hypersensitivity: a
practice parameter. Ann Allergy 1999;83(suppl):
S665–S700.
12. Diagnosis and management of urticaria: a practice
parameter. Ann Allergy 2000;85(suppl):S521-S544.
13. Allergen immunotherapy: a practice parameter. Ann
Allergy 2003;90(suppl):SI-S540.
14. Symptom severity assessment of allergic rhinitis:
part I. Ann Allergy 2003;91:105-14.
15. Disease management of atopic dermatitis: an updated
practice parameter. Ann Allergy 2004;93(suppl):
S1-S21.
16. Stinging insect hypersensitivity: a practice parameter
update. J Allergy Clin Immunol 2004;114:869-86.
17. The diagnosis and management of anaphylaxis: an
updated practice parameter. J Allergy Clin Immunol
2005;115(suppl):S483-S523.
S25