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Immunotherapy Safety for the Primary Care ... - U.S. Coast Guard

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Introduction<br />

• “Anaphylaxis”<br />

– Word first coined by Portier and Richet in 1902.<br />

– While attempting to immunize dogs to sea anemone venom,<br />

<strong>the</strong> dogs unexpectedly died after a previously non-lethal<br />

dose.<br />

– They had unwittingly sensitized <strong>the</strong> animals.<br />

– This phenomenon was opposed to <strong>the</strong>ir goal of prophylaxis<br />

so <strong>the</strong>y referred to it as anaphylaxis, meaning “against<br />

protection”.

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