2009-2010 Bulletin – PDF - SEAS Bulletin - Columbia University

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Prerequisites: CHEM C1404 and MATH V1202.
Corequisite: BIOL C2005 or the equivalent.
Introduction to the thermodynamics of biological
systems, with a focus on connecting microscopic
molecular properties to macroscopic states. Both
classical and statistical thermodynamics will be
applied to biological systems; phase equilibria,
chemical reactions, and colligative properties.
Topics in modern biology, macromolecular behavior
in solutions and interfaces, protein-ligand binding,
and the hydrophobic effect.
BMEN E4300y Solid biomechanics
Lect: 3. 3 pts. Professor Mow.
Prerequisites: MECE E3105 and ENME E3113.
This course introduces applications of continuum
mechanics to the understanding of various biological
tissue properties. The structure, function, and
mechanical properties of various tissues in biological
systems, such as blood vessels, muscle, skin,
brain tissue, bone, tendon, cartilage, ligaments,
etc., will be examined. The focus will be on the
establishment of basic governing mechanical principles
and constitutive relations for each tissue.
Experimental determination of various tissue
properties will be introduced and demonstrated.
The important medical and clinical implications of
tissue mechanical behavior will be emphasized.
BMEN E4301x Structure, mechanics, and
adaptation of bone
Lect: 3. 3 pts. Instructor to be announced.
Introduction to structure, physiology, and biomechanics
of bone. Structure, function, and physiology
of skeletal bones; linear elastic properties of cortical
and trabecular bone; anisotropy and constitutive
models of bone tissue; failure and damage mechanics
of bone; bone adaptation and fracture healing;
experimental determination of bone properties; and
morphological analysis of bone microstructure.
BMEN E4305y Cardiac mechanics
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisites: BMEN E3310 and E3320 or equivalents.
Cardiac anatomy, passive myocardial constitutive
properties, electrical activation, ventricular
pump function, ventricular-vascular coupling,
invasive and noninvasive measures of regional
and global function, models for predicting ventricular
‘wall stress. Alterations in muscle properties
and ventricular function resulting from myocardial
infarction, heart failure, and left ventricular assist.
BMEN E4340y Introduction to cell mechanics
Lect: 3. 3 pts. Professor Jacobs.
Prerequisite: BMEN E3320. Introduction to how
cells function as mechanical structures and how
mechanical factors influence cellular behavior.
Topics include basics of cell biology, continuum
mechanics, and statistical mechanics. Concepts
applied to the mechanical behavior of cells,
cytoskeletal polymers, polymer networks, and
membranes. Experimental approaches in cell
mechanics are surveyed and compared and
mechanics of cellular motility and adhesion analyzed.
The mechanobiology of contractile cells
including fibroblasts and myocytes; cell and
molecular biology of mechanosensing by cells
such as stem cells, chondrocytes, osteoblasts,
and osteocytes.
BMEN E4400x Wavelet applications in
biomedical image and signal processing
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisite: The instructor’s permission. An
introduction to methods of wavelet analysis and
processing techniques for the quantification of
biomedical images and signals. Topics include
frames and overcomplete representations, multiresolution
algorithms for denoising and image
restoration, multiscale texture segmentation and
classification methods for computer-aided diagnosis.
BMEN E4410y Principles of ultrasound in
medicine
Lect: 3. 3 pts. Professor Konofagou.
Prerequisite: Calculus, Fourier analysis. Physics
of diagnostic ultrasound and principles of ultrasound
imaging instrumentation. Propagation of
plane waves in lossless media; ultrasound propagation
through biological tissues; single-element
and array transducer design; pulse-echo and
Doppler ultrasound instrumentation, performance
evaluation of ultrasound imaging systems using
tissue-mimicking phantoms, ultrasound tissue
characterization; ultrasound nonlinearity and bubble
activity; harmonic imaging; acoustic output of
ultrasound systems; biological effects of ultrasound.
BMEN E4420y Biomedical signal processing
and signal modeling
Lect: 3. 3 pts. Professor Sajda.
Prerequisites: APMA E3101 and ELEN E3202,
or the instructor’s permission. Fundamental concepts
of signal processing in linear systems and
stochastic processes. Estimation, detection, and
filtering methods applied to biomedical signals.
Harmonic analysis, auto-regressive model,
Wiener and matched filters, linear discriminants,
and independent components. Methods are
developed to answer concrete questions on specific
data sets in modalities such as ECG, EEG,
MEG, Ultrasound. Lectures accompanied by data
analysis assignments using MATLAB.
BMEN E4430x Principles of magnetic
resonance imaging
Lect: 3. 3 pts. Professor Brown.
Prerequisite: APMA E1201, PHYS C1403, or the
instructor’s permission. Fundamental principles
of Magnetic Resonance Imaging (MRI), including
the underlying spin physics and mathematics of
image formation with an emphasis on the application
of MRI to neuroimaging, both anatomical and
functional. The course will examine both theory
and experimental design techniques.
BMEN E4440y Physiological control systems
Lect: 3. 3 pts. Professor Chbat.
Prerequisites: APMA E2101 and instructor’s permission
or senior standing. Dynamic system modeling
and simulation of cardiovascular, respiratory,
and thermoregulatory systems. Open and closed
physiological loops. Internal and external controllers:
baroreflex, chemoreflex, and ventilator.
Fundamentals of time and frequency domain
analyses and stability. Emulation of normal and
pathophysiological conditions. Clinical relevance
and decision support. Matlab and SIMULINK
programming environments will be utilized.
BMEN E4450y Dental and craniofacial tissue
engineering
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisites: MSAE E3103, BMEN E4210, and
BMEN E4501 or equivalent. Principles of dental and
craniofacial bioengineering, periodontal tissue engineering;
beyond guided tissue regeneration, craniofacial
regeneration by stem cells and engineered
scaffolds, biomaterials. Engineering approaches in
tissue regeneration, bone biology and development;
instructive cues for tissue engineers.
BMEN E4501x Tissue engineering, I:
biomaterials and scaffold design
Lect: 3. 3 pts. Professor H. H. Lu.
Prerequisites: BIOL C2005-C2006, BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria in
the development of biomaterials and tissue engineered
grafts. Material structural-functional relationships,
biocompatibility in terms of material and
host responses. Through discussions, readings,
and a group design project, students acquire an
understanding of cell-material interactions and
identify the parameters critical in the design and
selection of biomaterials for biomedical applications.
BMEN E4502y Tissue engineering, II:
biological tissue substitutes
Lect: 3. 3 pts. Professor Hung.
Prerequisites: BIOL C2005-C2006 and BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria
behind the development of cell-based tissue substitutes.
Topics include biocompatibility, biological
grafts, gene therapy-transfer, and bioreactors.
BMEN E4540y Bioelectrochemistry
Lect: 3. 3 pts. Professor Pilla.
Prerequisite: Elementary physical and organic
chemistry. Application of electrochemical kinetics
to interfacial processes occurring in biomedical
systems. Basics of electrochemistry, electrochemical
instrumentation, and relevant cell and electrophysiology
reviewed. Applications to interpretation
of excitable and nonexcitable membrane phenomena,
with emphasis on heterogeneous mechanistic
steps. Examples of therapeutic devices created
as a result of bioelectrochemical studies.
BMEN E4550y Micro- and nano-structures in
cellular engineering
Lect: 3. 3 pts. Professor Kam.
Prerequisites: BIOL W2005 and BIOL W2006 or
SEAS 2009–2010