2009-2010 Bulletin – PDF - SEAS Bulletin - Columbia University

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first (basic notions, synthesis, properties of single
polymer molecules, polymer solution and blend
thermodynamics, rubber and gels). Colloidal
systems are treated next (dominant forces in
colloidal systems, flocculation, preparation and
manipulation of colloidal systems) followed by a
discussion of self-organizing surfactant systems
(architecture of surfactants, micelles and surfactant
membranes, phase behavior).
CHEN E4640x or y Polymer surfaces and
interfaces
Lect: 3. 3 pts. Instructor to be announced.
Prerequisites: CHEN E4620 or the instructor’s
permission. A fundamental treatment of the thermodynamics
and properties relating to polymer
surfaces and interfaces. Topics include the characterization
of interfaces, theoretical modeling of
interfacial thermodynamics and structure, and
practical means for surface modification.
CHEN E4645x or y Inorganic polymers, hybrid
materials and gels
Lect: 3. 3 pts. Professor Koberstein.
Prerequisite: Organic chemistry. The focus of the
first part of the course is on the preparation, characterization,
and applications of inorganic polymers,
with a heavy emphasis on those based on
main-group elements. Main topics are characterization
methods, polysiloxanes, polysilanes,
polyphosphazenes, ferrocene-based polymers,
other phosphorous-containing polymers, boroncontaining
polymers, preceramic inorganic polymers,
and inorganic-organic hybrid composites.
The focus of the second part of the course is on
gels, both physical and chemical. Topics will
include gel chemistry, including epoxies,
polyurethanes, polyesters, vinyl esters, and
hydrogels, as well as theoretical methods used
to characterize the gel point and gel properties.
CHEN E4660y Biochemical engineering
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisite: BMEN E4001 or the equivalent.
Engineering of biochemical and microbiological
reaction systems. Kinetics, reactor analysis, and
design of batch and continuous fermentation and
enzyme processes. Recovery and separations in
biochemical engineering systems.
CHEN 4680x Soft materials laboratory
Lect/lab: 3. 3 pts. Professors Durning and
Koberstein.
Prerequisites: Two years of undergraduate
science courses and the instructors’ permission.
Covers modern characterization methods for soft
materials (polymers, complex fluids, biomaterials).
Techniques include diffential scanning calorimetry,
dynamic light scattering, gel permeation chromatography,
rheology, and spectroscopic methods.
Team taught by several faculty and open to
graduate and advanced undergraduate students
(limit 15).
CHEN E4700x Principles of genomic
technologies
Lect: 3. 3 pts. Professor Ju.
Prerequisites: BIOL C2005 and 2006, CHEM
C3045 and C3046, or equivalents. Chemical
and physical aspects of genome structure and
organization, genetic information flow from DNA
to RNA to protein. Nucleic acid hybridization and
sequence complexity of DNA and RNA. Genome
mapping and sequencing methods. The engineering
of DNA polymerase for DNA sequencing and
polymerase chain reaction, Fluorescent DNA
sequencing and high-throughput DNA sequencer
development. Construction of gene chip and
micro array for gene expression analysis. Technology
and biochemical approach for functional
genomics analysis. Gene discovery and genetics
database search method. The application of
genetic database for new therapeutics discovery.
CHEN E4740x: Biological transport and rate
phenomena, II
Lect: 3. 3 pts. Professor Leonard.
Prerequisites: Any two of the following: CHEN
E3110; BIOL C2005; CHEN E3210 or BMCH
E3500. Analysis of transport and rate phenomena
in biological systems and in the design of biomimetic
transport-reaction systems for technological
and therapeutic applications. Modeling of
homogeneous and heterogeneous biochemical
reactions. The bases of biological transport: roles
of convection, ordinary diffusion, forced diffusion.
Systems where reaction and transport interact
strongly. Applications to natural and artificial tissue
beds, tumor modeling, controlled release,
natural and artificial organ function.
CHEN E4750y The genome and the cell
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisite: BIOL C2005 and MATH E1210, or
equivalents. The utility of genomic information lies
in its capacity to predict the behavior of living cells
in physiological, developmental, and pathological
situations. The effect of variations in genome structure
between individuals within a species, including
those deemed healthy or diseased, and among
species, can be inferred statistically by comparisons
of sequences with behaviors, and mechanistically,
by studying the action of molecules whose
structure is encoded within the genome. This
course examines known mechanisms that elucidate
the combined effect of environmental stimulation
and genetic makeup on the behavior of cells in
homeostasis, disease states, and during development,
and includes assessments of the probable
effect of these behaviors on the whole organism.
Quantitative models of gene translation and intracellular
signal transduction will be used to illustrate
switching of intracellular processes, transient and
permanent gene activation, and cell commitment,
development, and death.
CHEN E4760y Genomics sequencing laboratory
Lect: 1. Lab: 2. 3 pts. Professor Ju.
Prerequisites: Undergraduate-level biology, organic
chemistry, and the instructor’s permission. The
chemical, biological, and engineering principles
involved in the genomics sequencing process will
be illustrated throughout the course for engineering
students to develop the hands-on skills in conducting
genomics research.
CHEN E4800x Protein engineering
Lect: 3. 3 pts. Professor Banta.
Prerequisite: CHEN E4230 (may be taken
concurrently) or the instructor’s permission.
Fundamental tools and techniques currently used
to engineer protein molecules. Methods used to
analyze the impact of these alterations on different
protein functions, with specific emphasis on
enzymatic catalysis. Case studies reinforce concepts
covered and demonstrate the wide impact
of protein engineering research. Application of
basic concepts in the chemical engineering curriculum
(reaction kinetics, mathematical modeling,
thermodynamics) to specific approaches utilized
in protein engineering.
CHEN E6050y Advanced electrochemistry
Lect: 3. 3 pts. Not given in 2009–2010.
Prerequisite: The instructor’s permission. An
advanced overview of the fundamentals of electrochemistry,
with examples taken from modern
applications. An emphasis is placed on mass
transfer and scaling phenomena. Principles are
reinforced through the development of mathematical
models of electrochemical systems. Course projects
will require computer simulations. The course
is intended for advanced graduate students,
conducting research involving electrochemical
technologies.
CHEE E6220y Equilibria and kinetics in
hydrometallurgical systems
Lect: 3. 3 pts. Professor Duby.
Prerequisite: CHEE E4050 or EAEE E4003.
Detailed examination of chemical equilibria
in hydrometallurgical systems. Kinetics and
mechanisms of homogeneous and heterogeneous
reaction in aqueous solutions.
CHEE E6252y Applied surface and colloid
chemistry
Lect: 2. Lab: 3. 3 pts. Professor Somasundaran.
Prerequisite: CHEN E4252. Applications of surface
chemistry principles to wetting, flocculation,
flotation, separation techniques, catalysis, mass
transfer, emulsions, foams, aerosols, membranes,
biological surfactant systems, microbial surfaces,
enhanced oil recovery, and pollution problems.
Appropriate individual experiments and projects.
SEAS 2009–2010