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The Effect of Medical Advances on Insurance ... - Actuary.com

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Comm<strong>on</strong> Complex Diseases<br />

• No clear Mendelian pattern <str<strong>on</strong>g>of</str<strong>on</strong>g> inheritance (not<br />

directly predictable)<br />

• Genetic and envir<strong>on</strong>mental c<strong>on</strong>tributi<strong>on</strong>s likely<br />

• Variable penetrance/expressi<strong>on</strong><br />

• Occurrence <str<strong>on</strong>g>of</str<strong>on</strong>g> protective and susceptibility genes<br />

• Familial aggregati<strong>on</strong>s may be seen<br />

• Includes most <str<strong>on</strong>g>of</str<strong>on</strong>g> the <strong>com</strong>m<strong>on</strong> diseases we<br />

underwrite:<br />

CVD, CA, Schizophrenia, DM, HCVD, AD,<br />

CVA, obesity,….

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