Tissue Banking Overview: Washington University Medical Center

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8/21/2012 Sample for diagnostic surgical pathology Yes, more tissue needed for microscopic diagnosis In effect, every region of every specimen is subjected to a threeway decision in the gross room! Option #1 Option #2 Sample for tissue banking (general or specific protocol) More for banking (rare, since tissue is fixed at this point) Is more tissue now needed for diagnosis? No Option #3 Do neither Specimen goes into formalin; kept for a short time following diagnostic signout Surgical biospecimens are often inadequate for molecular diagnostics • Many diseases and cases are not subject to surgical therapy • Many diseases and cases are not treatment naïve at the time of surgical therapy • Surgical therapy often occurs at only one time point in a patient’s clinical course • Surgical specimens experience tremendous preanalytical processing variability • Competing needs for traditional histopathology assessment • Requirement for minimally invasive, repeated sampling 16
8/21/2012 <strong>Tissue</strong> banking principles ‣ Changes made recently to surgical tissue collection/ transport practices which result in delivery of more tissue in “real time” (
Page 1 and 2: 8/21/2012 ICTS Brown Bag Seminar
Page 3 and 4: 8/21/2012 Washington University Med
Page 5 and 6: 8/21/2012 BJCIH Laboratory for Tran
Page 7 and 8: 8/21/2012 Classification of banked
Page 9 and 10: 8/21/2012 Specimen Collection • D
Page 11 and 12: 8/21/2012 Advantages of online syst
Page 13 and 14: 8/21/2012 Specimen QA • Specimen
Page 15: 8/21/2012 Specimen Storage • Ultr
Page 19 and 20: 8/21/2012 Acknowledgments • Sitem
Page 21 and 22: 8/21/2012 WUMC Biobanking 2011 Regu
Page 23 and 24: 8/21/2012 Contraindications to tiss
Page 25 and 26: 8/21/2012 Organ-specific contraindi
Page 27 and 28: 8/21/2012 “Adjacent normal” tis
Page 29 and 30: 8/21/2012 Tissue Microarrays Advant
Page 31 and 32: 8/21/2012 Operating Procedures for
Page 33 and 34: 8/21/2012 General procedure ‣ Use
Page 35 and 36: 8/21/2012 caTissue: Search Results
Page 37: 8/21/2012 Comparison between umbili

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