Tissue Banking Overview: Washington University Medical Center

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8/21/2012 Organ-specific contraindications: examples • Too little tissue typically available for banking, or all available tissue often needed for diagnosis – Brain tumors – Testicular tumors, especially germ cell neoplasms – Many diagnostic biopsies – Primary melanomas • Diagnoses where submission of most or all tissue is needed to substantiate a previous diagnosis or look for invasive areas – DCIS, LCIS, atypical endometrial hyperplasia Organ-specific contraindications: examples • Necessity to preserve landmarks important for surgical pathology evaluation – Capsule for thyroid masses – Surgical margins – Stalk for tubulovillous adenomas – Lymph node capsule in radical neck dissections • Gross/ microscopic correlation difficulties • Bony tumors requiring decalcification 24
8/21/2012 Organ-specific contraindications: examples • Necessity to preserve landmarks important for surgical pathology evaluation – Capsule for thyroid masses – Surgical margins – Stalk for tubulovillous adenomas – Lymph node capsule in radical neck dissections • Gross/ microscopic correlation difficulties • Bony tumors requiring decalcification Key issues for banked samples: our experience ‣samples received from outside sources may not be of the type or disease state advertised, or may be of poor quality, i.e. necrotic ‣certain cell types within a sample, such as epithelial lining or an inflammatory component, may need to be isolated specifically, rather than the whole tissue being digested in an expression assay ‣pigments, inflammatory infiltrates, preservation conditions, or other features may affect the intended performance of the tissue in an expression assay. 25
Page 1 and 2: 8/21/2012 ICTS Brown Bag Seminar
Page 3 and 4: 8/21/2012 Washington University Med
Page 5 and 6: 8/21/2012 BJCIH Laboratory for Tran
Page 7 and 8: 8/21/2012 Classification of banked
Page 9 and 10: 8/21/2012 Specimen Collection • D
Page 11 and 12: 8/21/2012 Advantages of online syst
Page 13 and 14: 8/21/2012 Specimen QA • Specimen
Page 15 and 16: 8/21/2012 Specimen Storage • Ultr
Page 17 and 18: 8/21/2012 Tissue banking principles
Page 19 and 20: 8/21/2012 Acknowledgments • Sitem
Page 21 and 22: 8/21/2012 WUMC Biobanking 2011 Regu
Page 23: 8/21/2012 Contraindications to tiss
Page 27 and 28: 8/21/2012 “Adjacent normal” tis
Page 29 and 30: 8/21/2012 Tissue Microarrays Advant
Page 31 and 32: 8/21/2012 Operating Procedures for
Page 33 and 34: 8/21/2012 General procedure ‣ Use
Page 35 and 36: 8/21/2012 caTissue: Search Results
Page 37: 8/21/2012 Comparison between umbili

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