Tissue Banking Overview: Washington University Medical Center
Tissue Banking Overview: Washington University Medical Center
Tissue Banking Overview: Washington University Medical Center
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8/21/2012<br />
Contraindications to tissue banking<br />
‣ small tumors and other cases where most<br />
lesional tissue is needed for diagnosis<br />
‣ surgical margins of resection<br />
‣ specimens where tumor and benign areas<br />
cannot be clearly delineated grossly<br />
‣ grossly visible areas of primarily necrosis,<br />
hemorrhage, or fat<br />
‣ specimens which are known to have been<br />
delayed significantly more than 30<br />
minutes past their procurement time in the<br />
OR<br />
‣ tissue previously freeze-thawed, or frozen<br />
slowly (e.g. in the cryostat or -80 freezer)<br />
Contraindications to tissue banking<br />
‣ areas of deepest invasion, tumor/normal<br />
interface, tumor/capsule interface,<br />
extranodal extension of tumor, and<br />
other key landmarks for surgical<br />
pathology evaluation and tumor staging<br />
‣ chemotherapy- or radiation-treated<br />
tumors with no gross residual tumor<br />
mass<br />
‣ diagnostic biopsies where most or all<br />
tissue must be submitted for pathology<br />
evaluation…most lymph node, GI,<br />
bone marrow, and liver biopsies<br />
fall in this category<br />
‣ tissue clearly marked as intended<br />
for a special study such as<br />
immunofluorescence<br />
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