Tissue Banking Overview: Washington University Medical Center

More documents

Recommendations

Info

8/21/2012 Pathologist roles in TMAs Selecting “donor” tissue blocks for TMA construction Selecting areas of “donor” blocks to obtain tissue core from Configuring TMA block parameters appropriately. For example, too many cores on a slide will yield smaller core areas. This raises the risk that edge artifacts from IHC staining will obscure useful information. Reviewing H&E slide for TMA blocks, for quality assurance purposes (i.e. making sure that appropriate tissues are represented in cores, and documenting if they are not) Operating Procedures for Specimen Evaluation Verify the pathology of all incoming tissues, storage of these interpretations in data files Communicate with outside tissue suppliers about our findings and any discrepancies with claimed diagnosis or tissue quality Consider the project goals and methods vs. the anatomic makeup of the tissue: What cells or component(s) of the tissue are key to the study or the choice of controls? 30
8/21/2012 Operating Procedures for Specimen Evaluation Supply H&E sections matching the provided tissue, with relevant areas of disease marked Oncology: areas of tumor, pre-malignant change, normal adjacent tissue, overall % tumor cellularity Atherosclerosis: areas of plaque (stable and unstable) vs. normal vessel wall Collection Limitations • Surgically Inaccessible Previous resection Brain metastasis Small cell lung cancer • Limiting Material FNA DCIS • Sampling Error Prostate cancer • Proper Collection Procedures Primary hospitals Academic centers • Insufficient Claim / Interest • Competition 31
Page 1 and 2: 8/21/2012 ICTS Brown Bag Seminar
Page 3 and 4: 8/21/2012 Washington University Med
Page 5 and 6: 8/21/2012 BJCIH Laboratory for Tran
Page 7 and 8: 8/21/2012 Classification of banked
Page 9 and 10: 8/21/2012 Specimen Collection • D
Page 11 and 12: 8/21/2012 Advantages of online syst
Page 13 and 14: 8/21/2012 Specimen QA • Specimen
Page 15 and 16: 8/21/2012 Specimen Storage • Ultr
Page 17 and 18: 8/21/2012 Tissue banking principles
Page 19 and 20: 8/21/2012 Acknowledgments • Sitem
Page 21 and 22: 8/21/2012 WUMC Biobanking 2011 Regu
Page 23 and 24: 8/21/2012 Contraindications to tiss
Page 25 and 26: 8/21/2012 Organ-specific contraindi
Page 27 and 28: 8/21/2012 “Adjacent normal” tis
Page 29: 8/21/2012 Tissue Microarrays Advant
Page 33 and 34: 8/21/2012 General procedure ‣ Use
Page 35 and 36: 8/21/2012 caTissue: Search Results
Page 37: 8/21/2012 Comparison between umbili

Tissue Banking Overview: Washington University Medical Center

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?