Tissue Banking Overview: Washington University Medical Center

More documents

Recommendations

Info

8/21/2012 Clinical tissue banking: Requirements for a successful program ‣ Close partnerships between pathologists, surgeons, and hospital adminstrators ‣ Demonstration of solid clinical value to hospital administration ‣ Pathologists’ assistants and other gross room staff with good knowledge of gross room techniques ‣ Knowledgeable tissue bank pathologist(s) and staff who understand the process and the value of good communication ‣ Transport personnel between operating rooms and pathology laboratory ‣ Instruction/ education process for staff and stakeholders Research vs. clinical tissue banking • In the past, tissue banking was regarded as primarily a research activity • Advent of molecular technologies has made the storage of fresh-frozen tissue for diagnostic purposes desirable; i.e. tissue banking can and should become a routine part of patient care - Specimens banked now and used later at an unspecified time - Results may be correlated with past or future clinical specimens, i.e. time becomes an added dimension of banking, especially advancing knowledge/ hypotheses • Consent and IRB expectations for clinical tissue banking should evolve similarly to other clinical processes, i.e. clinicians not needing specific IRB approval for diagnostic blood draws from patients - Clinical bank specimens would remain identified • In a sense, clinical tissue banking has always existed with paraffin block archives from surgical pathology; demand for fresh-frozen specimens driven by molecular/ genomic technologies is key 36
8/21/2012 Comparison between umbilical cord blood banking and clinical tissue banking Issue Comparison Comments Time dimension of the biobanking process Promotion of advantages of the procedure to physicians and patients Link to patient identity Accreditation In both fields, specimens are banked now for an uncertain but potentially high-impact use in the future; can be of benefit in ways not necessarily forseen at the time of procurement Communication/education is a central component of cord blood banking to increase use of the procedure; this is also likely true of clinical tissue banking Private (though not public) cord bank specimens linked to patient identity; required for clinical tissue banking Besides FDA regulations, the American Association of Blood Banks (AABB), (CAP) and the Foundation for the Accreditation of Cellular Therapy (FACT). Accreditation program for tissue banks (CAP) released in 2011. Education of users is required, since stakeholders often tend to value only those things that offer immediate benefits Helps overcome expectation and cost barriers, and helps the practice become more widely used Consent process distinct from that that used for biospecimen repositories focused on research Certification standards and accreditation programs enhance patient care; they will also increase patient and physician confidence in the overall enterprise, as well as the individual repositories they use 37
Page 1 and 2: 8/21/2012 ICTS Brown Bag Seminar
Page 3 and 4: 8/21/2012 Washington University Med
Page 5 and 6: 8/21/2012 BJCIH Laboratory for Tran
Page 7 and 8: 8/21/2012 Classification of banked
Page 9 and 10: 8/21/2012 Specimen Collection • D
Page 11 and 12: 8/21/2012 Advantages of online syst
Page 13 and 14: 8/21/2012 Specimen QA • Specimen
Page 15 and 16: 8/21/2012 Specimen Storage • Ultr
Page 17 and 18: 8/21/2012 Tissue banking principles
Page 19 and 20: 8/21/2012 Acknowledgments • Sitem
Page 21 and 22: 8/21/2012 WUMC Biobanking 2011 Regu
Page 23 and 24: 8/21/2012 Contraindications to tiss
Page 25 and 26: 8/21/2012 Organ-specific contraindi
Page 27 and 28: 8/21/2012 “Adjacent normal” tis
Page 29 and 30: 8/21/2012 Tissue Microarrays Advant
Page 31 and 32: 8/21/2012 Operating Procedures for
Page 33 and 34: 8/21/2012 General procedure ‣ Use
Page 35: 8/21/2012 caTissue: Search Results

Tissue Banking Overview: Washington University Medical Center

Create successful ePaper yourself

Delete template?

Save as template?