splice site
splice site
splice site
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Catalysis :<br />
1.Formation of the C complex produces the<br />
active <strong>site</strong>, with U2 and U6 RNAs being<br />
brought together<br />
2.Formation of the active <strong>site</strong> juxtaposes the 5’ 5<br />
<strong>splice</strong> <strong>site</strong> of the pre-mRNA and the branch<br />
<strong>site</strong>, allowing the branched A residue to attack<br />
the 5’ 5 <strong>splice</strong> <strong>site</strong> to accomplish the first<br />
transesterfication reaction.<br />
3.U5 snRNP helps to bring the two exons<br />
together, and aids the second<br />
transesterification reaction, in which the 3’-OH<br />
of the 5’ exon attacks the 3’ <strong>splice</strong> <strong>site</strong>.<br />
4.Release of the mRNA product and the snRNPs
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