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6.1 RNA editing is another way of<br />
changing the sequence of an mRNA<br />
I. Site specific deamination :<br />
(1)A specifically targeted C residue within<br />
mRNA is converted into U by the<br />
deamination.The process occurs only in<br />
certain tissues or cell types and in a<br />
regulated manner.<br />
(2)Adenosine deamination also occurs in cells.<br />
The enzyme ADAR (adenosine deaminase<br />
acting on RNA) convert A into Inosine.<br />
Insone can base-pair with C, and this change<br />
can alter the sequence of the protein. An ion<br />
channel expressed in mammalian brains is<br />
the target of Adenosine deamination.
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