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II Guide RNA-directed uridine insertion or<br />
deletion.<br />
1. This form of RNA editing is found in the<br />
mitochondria of trypanosomes.<br />
2. Multiple Us are inserted into specific region<br />
of mRNAs after transcription (or US may be<br />
deleted).<br />
3. The addition of Us to the message changes<br />
codons and reading frames, completely altering<br />
the “meaning” of the message.<br />
4. Us are inserted into the message by guide<br />
RNAs (gRNAs) .
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