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hnRNPs binds RNA and act as<br />
repressors :<br />
Most silencers are recognized by hnRNP<br />
( heterogeneous nuclear<br />
ribonucleoprotein) family.<br />
These proteins bind RNA, but lack the RS<br />
domains. Therefore, (1) They cannot<br />
recruit the splicing machinery. (2) they<br />
block the use of the specific <strong>splice</strong> <strong>site</strong>s<br />
that they bind.
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