splice site

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Two ways to enhance the accuracy of
the splice-site selection:
1. Because the C-terminal C
tail of the RNA
polymerase II carries various splicing proteins, co-
transcriptional loading of these proteins to the newly
synthesized RNA ensures all the splice sites emerging
from RNAP II are readily recognized, thus preventing
exon skipping.
2. There is a mechanism to ensure that the splice sites
close to exons are recognized preferentially. SR
proteins bind to the ESEs (exonic splicing enhancers)
present in the exons and promote the use of the
nearby splice sites by recruiting the splicing
machinery to those sites