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• Three observations suggest exon shuffling<br />
actually occur:<br />
1. The borders between exons and introns<br />
within a gene often coincide with the<br />
boundaries between domains within the<br />
protein encoded by that gene.<br />
2. Many genes, and proteins they encode,<br />
have apparently arisen during evolution in<br />
part via exon duplication and divergence.<br />
3. Related exons are sometimes found in<br />
unrelated genes.