Diffusion Processes with Hidden States from ... - FU Berlin, FB MI

4 Fluorescence Tracking Experimentsthe reaction rates. For this reason they use in their work a wide range of diffusion coefficients,both for rhodopsin and transducin, beginning with values at infinite dilution to those values atmuch more dense protein concentration. For rhodopsin they give diffusion coefficients in therange ofD R = 0.35 µm2 ,...,5.0 µm2 . (4.1)s sThey are pointing out that no diffusion coefficients for transducin were measured, but coefficientsfor other peripheral proteins (D P ) similar to transducin in the rangeD P = 5.0 µm2s,...,6.9 µm2 . (4.2)sSaxton and Owicki, and also later scientists point out that transducin at least moves as fast asrhodopsin but moreover faster. [6] for instance calculated a lower bound for the transducin diffusioncoefficient with a value of D lowT = 0.8 µm2s.In view of this considerations we have decided to choose for the transducin molecule diffusioncoefficient a relatively wide range, given byD T = 0.8 µm2s,...,7.0 µm2 . (4.3)sIn the following chapter we will focus on the modeling procedure based upon the experimentaltransducin trajectory data. We will stick to the above range in which the estimated diffusioncoefficients should also lie.If we calculate the range of noise intensities σ T according to the determined diffusion coefficients,we obtainσ T = (0.5,...,7.0) · 10 −35 Kg2 m 2−35 J · Kgs 3 = (0.5,...,7.0) · 10 , (4.4)swhere J is denoting joule, the unit of energy (heat).72