Managing the patient withshift-work disorderMichael J. Thorpy, MDDirector of the Sleep-Wake Disorders CenterMontefiore Medical CenterBronx, New YorkPractice re<strong>com</strong>mendationsy Behavioral measures, eg, exercise andimproved sleep hygiene, can enhancesleep quality and <strong>com</strong>bat insomniaand excessive sleepiness (ES) in shiftworkers and individuals with shiftworkdisorder (SWD) (SOR: B).y Napping before a shift followed byconsumption of a caffeinated drink and, ifappropriate, scheduled naps at work, mayimprove ES in patients with SWD (SOR: C).y Use of bright light therapy to partiallyre-entrain the circadian clock should beexplored for all night-shift workers—particularly those with SWD (SOR: B).y The wakefulness-promoting agentsarmodafinil and modafinil are FDA approvedfor the treatment of ES in patients with SWD.Alongside nonpharmacologic interventions,they can be included in a <strong>com</strong>prehensivemanagement plan for SWD (SOR: A).y Melatonin or other sleep-promotingagents may help shift workers achievesleep during required rest periods andwhen adjusting to night-shift work;studies are needed in patients with SWDto better evaluate the utility of theseagents in this population (SOR: C).Dr Thorpy reports that he serves as a consultantto and on the speakers bureaus of Cephalon, Inc.,and Jazz Pharmaceuticals, Inc.The goals of treatment for individuals with shift-workdisorder (SWD) are to ensure sustained wakefulnesswhen wakefulness is required and to facilitate restorativesleep when sleep is required. Several nonpharmacologicinterventions are available for the treatment of SWD, such asthe improvement of sleep hygiene, exercise, and timed exposureto light. Although these treatments are re<strong>com</strong>mended aspart of the Practice Parameter Guidelines for the Evaluationand Treatment of Circadian Rhythm Sleep Disorders fromthe American Academy of Sleep Medicine, 1,2 most have beenevaluated in shift workers generally, rather than specifically inthose with SWD. However, the current definition of SWD requiresfurther validation, and while the delineation betweenworkers who do not thrive under shift-work conditions andindividuals who develop SWD remains indistinct, it is likelythat literature specific to SWD will remain sparse. 2Regardless, such nonpharmacologic interventions shouldbe introduced for all individuals presenting with SWD. Pharmacotherapymay also be required. Two pharmacologic agents—modafinil and its R-enantiomer armodafinil—have beenevaluated specifically in patients with excessive sleepiness (ES)associated with SWD and are approved as wakefulness-promotingagents for this indication by the US Food and Drug Administration(FDA).This article reviews appropriate management strategiesand specific interventions—both nonpharmacologic andpharmacologic—that primary care physicians can offer toindividuals diagnosed with SWD.Addressing <strong>com</strong>orbid conditionsFor the individual presenting with SWD, it is essential to identifyand address any <strong>com</strong>orbid conditions that might contributeto poor sleep hygiene and/or cause ES or fatigue duringrequired periods of wakefulness. Perhaps the most relevant<strong>com</strong>orbidities are other sleep disorders, such as obstructivesleep apnea (OSA), and mood disorders, such as depression.Referral to a sleep specialist may be necessary for individualsS24 January 2010 / Vol 59, No 1 • Supplement to The Journal of Family Practice
with a suspected or confirmed <strong>com</strong>orbidsleep disorder (see “Recognition of shiftworkdisorder in primary care” on page S18of this supplement). An algorithm for themanagement of SWD in the primary caresetting, including steps to evaluate <strong>com</strong>orbiddisorders, appears in Figure 1.NonpharmacologicinterventionsA range of nonpharmacologic options havebeen evaluated to relieve the ES often reportedby shift workers. These interventionsinclude steps to improve sleep hygiene,scheduled nap times, exercise, andtimed exposure to light. Although not all ofthese interventions have been specificallyevaluated among individuals with SWD,such approaches may prove useful as partof a wider management program alongsidepharmacotherapy.figure 1 Primary care management algorithm for theindividual with shift-work disorder• Review currentsleep/wake patterns• Identify troublesomesymptoms• Review flexibility ofworking conditionsStep 1: EvaluateEvaluate for<strong>com</strong>orbid sleepdisordersEvaluate for<strong>com</strong>orbid medicaldisordersEvaluate for<strong>com</strong>orbid mooddisordersStep 2: Develop management strategyPriority A• Advise on sleep hygiene• Explore potential for changes toshift-work pattern• Explore potential for schedulednapping• Explore potential for simple brightlight therapyRefer for specialist careas appropriateRefer for specialist careas appropriateInitiate appropriatemedication and/orcounseling supportPriority B• Initiate a wakefulness-promotingagent• Consider use of sleep-promotingagents before the required sleepperiodEvaluating the work patternCertain shift patterns have been shown tobe more detrimental than others in terms oftheir effects on performance. 3 For example,Folkard and Tucker 3 analyzed data from 7studies that evaluated the risk for incidents(including accidents and injuries) during successivenight shifts. They found that the risk approximately doubledwith each shift worked, from ~6% during the secondnight shift to 17% during the third night shift and 36%during the fourth night shift (FIGURE 2). Additional studiesevaluating the effects of >4 consecutive night shifts, whichwere not included in the analysis by Folkard and Tucker, 3confirm the risk for decreased cognitive performance andincreased severe ES. 4,5 The observed marked increase inthe risk for incidents during working hours suggests thatworking more than 4 consecutive 12-hour night shiftsshould be avoided. Individuals should also be counseledto avoid work shifts that are longer than 12 hours due tothe risk accumulated on an hourly basis. 3 Individuals ona rotating shift schedule should be encouraged to rotatetheir shifts in a clockwise rather than a counterclockwisemanner (morning to evening to night shift as opposed tonight to evening to morning shift) (FIGURE 3). It is easier tochange the sleep/wake cycle to a clockwise shift rotation,as this follows the natural adaptive pattern of delayingthe sleep period. 6,7 However, a change of rotation directiondoes not eliminate the risks associated with SWD.Evaluate for changes in perceivedsleepiness (eg, Epworth SleepinessScale), accidents/near misses atwork or on the <strong>com</strong>mute homeFigure 2 Risk for incidents during successivenight shiftsRelative risk1.41.31.21.11.00.9Step 3: Review effectivenessRefer for specialist care and furthersleep/wake phase adjustment1 2 3 4Successive nightsReprinted from Occupational Medicine (London), Volume 53, Issue 2, FolkardS and Tucker P. Shift work, safety and productivity; pp 95–101, Copyright ©2003, with permission from Oxford University Press. 3Supplement to The Journal of Family Practice • Vol 59, No 1 / January 2010 S25
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