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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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• TiGenix’ success depends on i
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Unaudited pro forma income statemen
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Recent developmentsAcquisition of C
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In this context, we would like to s
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Announcement of the results of theO
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After the Contribution andafter the
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ContributionContribution AgreementC
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Risk factorsAny investment in the P
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commercialisation of ChondroCelect,
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in delays in bringing products to t
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The Company cannot predict what eff
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y each of its patents and patent ap
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to exercise preferential subscripti
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this prospectus which is capable of
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• investment professionals fallin
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1. General information and informat
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1.4.2 Company documents and otherin
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• the granting of discharge of li
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• in case of registered Shares, t
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cast at the meeting. If the amount
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No one may cast a greater number of
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If a Belgian resident individual ne
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Belgium has concluded tax treaties
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3. Information on the Contributiona
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In this context, we would like to s
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TiGenix has a limited financial deb
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Thousands of Euro (€) TiGenix Cel
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3.5.2 Issuance Price and RatioThe i
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(c)Rules for subscriptionSubject to
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The Scrips Private Placement will o
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to comply with any of its obligatio
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3.11.2 Scenario 1: Existing Shareho
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• a pledge of Locked Shares to a
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4. General information about THECOM
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DateINCORPORATIONFebruary 21,2000Tr
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Upon completion of the IPO of TiGen
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Issue dateMay 14,2004April 20,2005T
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4.7.2 Voting rightsAs further descr
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can be obtained free of charge at t
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5.2.4 Composition of the Board of D
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Amonis. Mr. Duron has been CEO of K
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5.3.4 Nomination and remunerationco
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• investor relations: nurturing c
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The remuneration of the members of
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5.7.2 Shares and warrants held by e
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Cellerix EBIP 2010An EBIP for senio
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The minutes must also contain a jus
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6. Activities of Tigenix andits sub
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• Clinical stage pipeline. TiGeni
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6.3.3 Acquisition of CellerixAs a r
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Full thickness articular cartilage
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Fig. 6.2: Autologous Chondrocyte Im
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Preclinical work in a meniscus repa
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The Company is also ensuring high q
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Recognising the importance of pre-l
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In Spain, since the passage of Orde
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- Page 135 and 136: 6.5.3 Commercial strategyBuilding o
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- Page 139 and 140: The international application WO06/
- Page 141 and 142: ChondroMimetic competitionThe main
- Page 143 and 144: in Cellerix’ GMP facility in Madr
- Page 145 and 146: 6.14.3 History and development of C
- Page 147 and 148: The table below gives an overview o
- Page 149 and 150: Prevalence No. of cases (2010) Esti
- Page 151 and 152: Fig. 6.9: Platform development stra
- Page 153 and 154: In developing Cx601, Cellerix has b
- Page 155 and 156: 6.14.6 Manufacturing & logisticsCel
- Page 157 and 158: population, methods for the isolati
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- Page 163 and 164: 7.2 Consolidated income statementTw
- Page 165 and 166: 7.3.1.2 Research and development ex
- Page 167 and 168: 7.3.2.3 Selling, general and admini
- Page 169 and 170: 7.4.1 Cash flows from operating act
- Page 171 and 172: Cash & cash equivalents and intangi
- Page 173 and 174: As of December 31, 2010, the Group
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- Page 177 and 178: 8.1.3 Consolidated cash flow statem
- Page 179 and 180: 8.1.5 Notes to consolidated financi
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- Page 187 and 188: 8.1.5.5 Personnel costsYears ended
- Page 189 and 190: 8.1.5.8 Loss per ShareBasic loss pe
- Page 191 and 192: 8.1.5.11 InventoriesThe carrying va
- Page 193 and 194: On April 23, 2009 a total of 6,790
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- Page 205 and 206: Years ended December 31Thousands of
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- Page 215 and 216: In view of the results of the FATT
- Page 217 and 218: InventoriesInventories are carried
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- Page 221 and 222: 9.1.5.6 Financial resultBelow is th
- Page 223 and 224: 9.1.5.8 Loss per shareThe basic los
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- Page 233 and 234: As of July 27, 2010, Cellerix’ bo
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9.1.5.25 Subsequent eventsContribut
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11. BUSINESS AND SCIENTIFIC Glossar
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Progenitor cellProteoglycansRARegen
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December 16, 2009Transparency Infor
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egulatory environment and to contri
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Appendix 3: Overview of Patentsand
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TitleMarker genes for use in the id
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B. Patents of CellerixThe table bel
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C. Trademarks of TiGenix and its su
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Appendix 4: BibliographyThe followi
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Hunziker, E. B., Quinn, T. M., and
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Von Der, Mark K., Gauss, V., von de
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CELLERIX S.A.MANAGEMENT REPORT(Fina
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1. The year in briefThe Company has
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3. Business developmentCellerix is
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(l)The contracting of services rela
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9. Post-balance sheet eventsOn 25 F
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CELLERIX S.A.MANAGEMENT REPORT(Fina
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1. The year in brief2009 was a very
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4. Business development7. Sharehold
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Decisions will be adopted by absolu
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CELLERIX S.A.MANAGEMENT REPORT(Fina
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1. The year in brief2008 has been a
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4. Business developmentIn 2008 Cell
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(l) The contracting of services rel
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ANNUAL FINANCIAL REPORT 2010TiGenix