3.2.2 Capitalisation and indebtednessThe following table sets forth <strong>TiGenix</strong>’ and Cellerix’capitalisation and indebtedness under IFRS, as well as forthe combined <strong>TiGenix</strong> - Cellerix group. This table should beread in conjunction with the Company’s and Cellerix’ auditedinformation in IFRS (see chapters 8 and 9), including the notesthereto and with the “Management’s discussion and analysisof <strong>TiGenix</strong>’ financial condition and result of operations” (seechapter 7) and “Appendix 5: 2008, 2009 and <strong>2010</strong> managementreports of Cellerix”.Thousands of Euro (€) <strong>TiGenix</strong> CellerixThreemonthsendingMarch 31,2011TwelvemonthsendingDecember 31,<strong>2010</strong>ThreemonthsendingMarch 31,2011TwelvemonthsendingDecember 31,<strong>2010</strong>Combined<strong>TiGenix</strong> – Cellerix groupThreemonthsendingMarch 31,2011TwelvemonthsendingDecember 31,<strong>2010</strong>Share capital 25,197 25,197 104 104 25,301 25,301Share premium 73,357 73,357 41,631 41,631 114,988 114,988Own shares and equity investments 0 0 (78) (78) -78 -78Shares to be issued 2,296 2,296 0 0 2,296 2,296Share-based compensation* 4,185 4,185 2,128 2,128 6,313 6,313Translation reserves* -355 -355 0 0 -355 -355Total Equity 104,680 104,680 43,785 43,785 148,465 148,465Non current debts 518 570 2,027 1,798 2,545 2,368Subordinated loan 98 130 0 0 98 130Financial loan** 420 440 2,027 1,798 2,447 2,238Current debts 216 222 15,260 1,162 15,476 1,384Subordinated loan 130 130 0 0 130 130Financial loan 80 80 1,186 1,162 1,266 1,242Shareholders advance payment *** 14,074 0 14,074 0Leases 6 12 0 0 6 12Total Financial Debt 734 792 17,287 2,960 18,021 3,752Gearing ratio (Financial debt/Equity) 0.70% 0.76% 39.48% 6.76% 12.14% 2.53%Cash & cash equivalents 2,160 5,555 15,120 3,786 17,280 9,341Net current financial indebtedness 1,944 5,333 -141 2,624 1,803 7,957Non current financial indebtedness -518 -570 -2,027 -1,798 -2,545 -2,368* Represents the situation at December 31, <strong>2010</strong>.** Regarding the €1,798K in Cellerix at 31/12/<strong>2010</strong>, there is a difference with the annual statements (€1,830k) of €32k. This difference is not related to financial loansand therefore has not been included in order to make information comparable.*** This amount refers to a part of the capital increase in cash for the total amount of €18,155,669.74 made by Cellerix Shareholders and other investors prior to theContribution.59 •
<strong>TiGenix</strong> has a limited financial debt position of €734k:• The financial lease obligations for at total amount of €6k(current portion: €0k) are secured by the related assets forthe same amount.• The financial loans amounting in total to €500k (currentportion: €80k) are granted upon condition to maintain thenet assets of the Group (total equity) on minimum €4,500kand to have a minimum solvability ratio (total equity/totalequity and liabilities) of 40%. These conditions are met.Cellerix´ only guaranteed loan is the credit facility with ETVCapital, S.A., as explained in section 9.1.5.16 of this prospectus.To guarantee this loan, Cellerix has made the followingcommitments:• to offer an option to purchase shares in Cellerix linked to thetranches established in the agreement;• that Cellerix’ debt levels during the life of the agreement,without considering the working capital generated inthe ordinary course of business, the loans received fromthe Spanish Ministry of Education and Science and fromEmpresa Nacional de Innovación, S.A. and the debtgenerated by the financing of the plant construction, willnot be more than €1 million greater than the value of theoutstanding repayments due to ETV Capital, S.A;• to grant power of attorney to ETV Capital, S.A. to establish amortgage guarantee over its intellectual property rights; and• to pledge the credit rights Cellerix holds in bankinginstitutions, represented by the balance of the funds ofwhich Cellerix is the holder in any of the bank accounts.This pledge may be exercised by ETV Capital, S.A. whenit considers that an event of termination under the loanagreement has occurred.3.2.3 Unaudited pro forma financialinformation of the enlarged GroupThe following financial information sets out a pro forma incomestatement and statement of financial position of the combined<strong>TiGenix</strong> - Cellerix group as at December 31, <strong>2010</strong>.This pro forma financial information has been prepared forillustrative purposes only and, because of its nature, it addressesa hypothetical situation and cannot give a complete picture ofthe actual financial position or results of the combined <strong>TiGenix</strong>- Cellerix group. The pro forma financial information is basedupon the audited consolidated financial statements of <strong>TiGenix</strong>as at December 31, <strong>2010</strong> and the audited financial statementsof Cellerix as at December 31, <strong>2010</strong>.3.2.3.1 Pro forma income statementThousands of Euro (€) <strong>TiGenix</strong> Cellerix Pro FormaCOMBINED INCOME STATEMENTSales billed 982 982Deferred sales (361) (361)Sales 621 105 726Other revenues 1,802 603 2,405Revenues 2,423 708 3,131Cost of sales (860) (860)Gross profit 1,563 708 2,271Research and development expenses 9,873 6,176 15,848Selling, general and administrative expenses 8,353 4,678 13,232Other operating income 0 0 0Other operating expenses 0 0 0Total operating charges 18,226 10,854 29,080Operating Result (EBIT) (16,663) (10,146) (26,809)Financial result 579 (197) 382Profit/(Loss) before taxes (16,084) (10,343) (26,427)Income taxes 368 0 368Net Profit/(Loss) (15,716) (10,343) (26,059)Basic loss per share (0.51) (1.47) (0.34)*60 • <strong>TiGenix</strong> • Rights Offering
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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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- Page 89 and 90: DateINCORPORATIONFebruary 21,2000Tr
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Full thickness articular cartilage
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Fig. 6.2: Autologous Chondrocyte Im
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Preclinical work in a meniscus repa
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The Company is also ensuring high q
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Recognising the importance of pre-l
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In Spain, since the passage of Orde
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Fig. 6.6: ChondroMimetic procedure
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6.5.3 Commercial strategyBuilding o
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6.7 Manufacturing & logisticsEffici
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The international application WO06/
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ChondroMimetic competitionThe main
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in Cellerix’ GMP facility in Madr
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6.14.3 History and development of C
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The table below gives an overview o
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Prevalence No. of cases (2010) Esti
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Fig. 6.9: Platform development stra
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In developing Cx601, Cellerix has b
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6.14.6 Manufacturing & logisticsCel
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population, methods for the isolati
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• Cimzia (certolizumab) - UCB: Al
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Spanish Ministry of Education and S
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7.2 Consolidated income statementTw
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7.3.1.2 Research and development ex
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7.3.2.3 Selling, general and admini
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7.4.1 Cash flows from operating act
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Cash & cash equivalents and intangi
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As of December 31, 2010, the Group
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8. Consolidated Financial informati
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8.1.3 Consolidated cash flow statem
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8.1.5 Notes to consolidated financi
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operating results and operating pla
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The Group does not account for work
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8.1.5.4 Operating result (EBIT)Resu
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8.1.5.7 TaxesThere is no current ta
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8.1.5.10 Tangible assetsThousands o
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8.1.5.14 Deferred charges & accrued
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8.1.5.18 Finance lease obligations
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Business combination Cellerix SADes
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Weighted averageexercise priceTOTAL
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the respective issue date of the wa
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Transactions with non-executive dir
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8.1.5.28 Subsequent eventsAcquisiti
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8.1.5.31 Disclosure under Article 1
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Additional statementsThe preparatio
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9.1.2 Stand-alone balance sheetYear
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9.1.4 Stand-alone statement of chan
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) Standards and interpretations iss
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The clinical development of new dru
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future against which they may be ap
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Cellerix’ research and developmen
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YearThousandsof Euro2010 2009 2008E
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Thousands of Euro (€)Laboratoryeq
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Current financial assetsShown below
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At December 31, Cellerix’ share c
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9.1.5.17 Deferred revenueThe balanc
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9.1.5.21 Share-based paymentsThe EB
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GrantsCellerix received several gra
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10. Report regarding unaudited prof
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EMAFDAFibrous tissueGCPGMPGrowth fa
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Appendix 1: Press releases 2006-201
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Appendix 2: REGULATORY APPROVALPROC
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like ChondroCelect or the future ce
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TitleCountry/regionPatent/applicati
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TitleCountry/regionPatent/applicati
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Title“Cell populations having imu
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D. Trademarks of CellerixThe table
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Decision resources.Dell’Accio, F.
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Noyes, F. R., Barber-Westin, S. D.,
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Appendix 5: 2008, 2009 and2010 mana
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Contents1. The year in brief ......
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2. Financial informationa. The Inco
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The Directors shall call a Sharehol
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• Exercise price changed to 5.291
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10 • TiGenix • Rights Offering
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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Exceptionally, for the following re
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(d)(e)Duration: The Options Plan wi
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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eceipt sent to the number or addres
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THE COMPANYTiGenix NVRomeinse straa