ANNUAL FINANCIAL REPORT 2010 2010 - TiGenix

Appendix 1: Press releases 2006-2010Below is a summary of the press releases issued by TiGenix in 2006, 2007, 2008, 2009 and 2010 (year-to-date). For further informationrelating to the contents of these press releases, referral is made to the Company’s website www.tigenix.com.January 5, 2006TiGenix closes €16 million Series B financing round and expands shareholder base worldwideMarch 28, 2006TiGenix establishes US presenceJanuary 11, 2007TiGenix expands management teamJanuary 24, 2007TiGenix and Fidia Advanced Biopolymers enter into strategic partnershipFebruary 19, 2007TiGenix announces positive Phase III results and plans listing on Eurolist by Euronext BrusselsMarch 9, 2007TiGenix to raise up to €40 million through IPOMarch 20, 2007Early closing of TiGenix public offerMarch 21, 2007Successful TiGenix IPO prompts early closingMarch 23, 2007TiGenix raises additional €6.0 million by exercise of over-allotment option. Total proceeds of IPO increase to€46.0 millionMay 7, 2007TiGenix and Cognate BioServices join forces for the management of a US cell expansion facilityJune 1, 2007TiGenix announces the acquisition of a US cell expansion facilityJune 19, 2007TiGenix files for marketing approval of ChondroCelect® in EuropeAugust 30, 2007 Business update and financial results for first half of 2007November 28, 2007TiGenix announces changes to Board of DirectorsFebruary 5, 2008Publication of ChondroCelect pivotal trial results in the American Journal of Sports MedicineFebruary 20, 2008TiGenix announces changes to Board of DirectorsMarch 20, 2008TiGenix gives business update and announces the full year 2007 financial resultsApril 28, 2008Three-year patient follow-up confirms clinical benefit of ChondroCelect®June 2, 2008Financial updateJune 10, 2008TiGenix awarded European Union grantAugust 28, 2008 Business update and financial results for first half of 2008September 15, 2008Publication in accordance with the Law of May 2, 2007 on the disclosure of major holdingsNovember 3, 2008Disclosure of major shareholdingsNovember 5, 2008 Business and financial update for the third quarter of 2008December 12, 2008TiGenix receives a €1.8 million grant for its meniscus repair program over the next two yearsMarch 16, 2009TiGenix gives business update and announces the full year 2008 financial resultsMay 19, 2009 Business and financial update for the third quarter of 2009June 19, 2009TiGenix selects location and secures financing for its new cell expansion facilityJune 26, 2009Update on capital increaseJune 26, 2009TiGenix receives positive CHMP opinion on European MAA for ChondroCelectJuly 10, 2009Transparency informationJuly 13, 2009Publication of ChondroCelect pivotal trial awards honoured with prestigious awardAugust 26, 2009 Business update and financial results for first half of 2009October 6, 2009ChondroCelect approved in EuropeOctober 29, 2009ChondroCelect 36 month data published in the American Journal of Sports MedicineNovember 2, 2009The ChondroCelect Harvester TM receives CE mark approvalNovember 3, 2009 Business and financial update for the third quarter of 2009November 5, 2009TiGenix comments on rumours of a capital increaseNovember 16, 2009TiGenix to acquire OrthomimeticsDecember 1, 2009TiGenix closes Orthomimetics acquisitionDecember 10, 2009TiGenix announces private placementDecember 10, 2009TiGenix successfully completes private placement raising €7.7 million229 •