Weighted averageexercise priceTOTALWarrantsissued inOutstanding 31 Dec ‘08 4.80 1,335,736 359,500 523,750 295,663 45,268 111,555Granted 3.97 170,200 170.200Lapsed 4.39 (8,250) (2,000) (4,000) (2,250)Exercised 3.00 (6,790) (6,790)ExpiredOutstanding 31 Dec ‘09 4.72 1,490,895 168,200 355,500 521,500 295,663 45,268 104,765Exercisable 31 Dec ‘09 3.43 223,064 - 88,875 - - 29,424 104,765Creation date Mar 12,<strong>2010</strong>June 19,2009Mar 20,2008Febr 26,2007Nov 03,2005April 20,2005May 14, 2004Total number created 500,000 500,000 400,000 800,000 454,570 45,268 135,802Outstanding 31 Dec ‘09 4.72 1,490,896 0 168,200 355,500 521,500 295,663 45,268 104,765Granted 2.58 372,000 372,000Lapsed 4.31 (87,812) (7,000) (13,000) (55,125) (10,687) (2,000)Exercised 3.45 (2,500) (2,500)ExpiredOutstanding 31 Dec ‘10 4.29 1,772,584 365,000 155,200 297,875 510,813 293,663 45,268 104,765Exercisable 31 Dec ‘10 3.56 631,433 38,800 148,938 - 293,663 45,268 104,765Warrants issued in March 2000 for the foundersBy a decision of the extraordinary shareholders’ meeting ofMarch 13, 2000, the Company issued 375,000 warrants. On thedate of this prospectus, all such warrants have been exercised.Warrant issued in March 2001 for employees, directors, andconsultantsBy a decision of the extraordinary shareholders’ meeting ofMarch 22, 2001, the Company issued 120,000 warrants. Onthe date of this prospectus, all such warrants either havebeen exercised (50,000 warrants) or have lapsed or expired(70,000 warrants).Warrants issued in September 2003 for employees, directors,and consultantsBy a decision of the extraordinary shareholders’ meeting ofSeptember 15, 2003, the Company issued 632,439 warrantsgiving the beneficiaries the right to subscribe to shares in theCompany of class B or D. By a decision of the extraordinaryshareholders’ meeting of September 30, 2003, the Companyissued an additional 151,851 warrants giving the beneficiariesthe right to subscribe to shares in the Company of type B or D.The warrants were granted with an exercise price equal to thefair market price of the underlying shares at the date of grant.The warrants were granted to selected beneficiaries bydecision of the board of directors. Under this plan, 25% of thewarrants become vested on each anniversary of the date ofthe grant, provided that the beneficiary still has a relationshipwith the Company via an employment agreement, a director’smandate or another collaboration agreement. The warrantscan only be exercised once vested, it being understood thatthey can only be exercised as from January 1 of the fourth yearfollowing the year in which they are granted (i.e., from January1, 2007 onwards for warrants granted in 2003). Non-exercisablewarrants become exercisable in case of an IPO or trade sale ofthe Company. All warrants were granted for free. The durationof the warrants is 5 years as of the issue date of the warrants.Warrants that have not been exercised within 5 years of theircreation become null and void.On the date of this prospectus, none of these warrants areoutstanding.Warrants issued in May 2004 for employees, directors, andconsultantsBy a decision of the extraordinary shareholders’ meeting ofMay 14, 2004, the Company issued 135,802 warrants giving thebeneficiaries the right to subscribe to shares of the Company ofclass B or D. The warrants were granted with an exercise priceequal to the fair market price of the underlying common sharesat the date of grant.187 •
The warrants were granted to selected beneficiaries bydecision of the board of directors. Under this plan, 25% of thewarrants become vested on each anniversary of the date ofthe grant, provided that the beneficiary still has a relationshipwith the Company via an employment agreement, a director’smandate or another collaboration agreement. The warrantscan only be exercised once vested, it being understood thatthey can only be exercised as from January 1 of the fourth yearfollowing the year in which they are granted (i.e., from January1, 2008 onwards for warrants granted in 2004). Non-exercisablewarrants become exercisable in case of an IPO or trade sale ofthe Company. All warrants were granted for free. The durationof the warrants is 5 years as of the issue date of the warrants.Warrants that have not been exercised within 5 years of theircreation become null and void 80 .On the date of this prospectus, 6,790 warrants were exercised.Warrants issued in April 2005 for employees, directors,and consultantsBy a decision of the extraordinary shareholders’ meeting ofApril 20, 2005, the Company issued 45,268 warrants giving thebeneficiaries the right to purchase shares of the Company ofclass B or D. The warrants were granted with an exercise priceequal to the fair market price of the underlying common sharesat the date of grant.The warrants were granted to selected beneficiaries bydecision of the board of directors. Under this plan, 25% of thewarrants become vested on each anniversary of the date ofthe grant, provided that the beneficiary still has a relationshipwith the Company via an employment agreement, a director’smandate or another collaboration agreement. The warrantscan only be exercised once vested, it being understood thatthey can only be exercised as from January 1 of the fourth yearfollowing the year in which they are granted (i.e., from January1, 2009 onwards for warrants granted in 2005). Non-exercisablewarrants become exercisable in case of an IPO or trade sale ofthe Company. All warrants were granted for free. The durationof the warrants is 5 years as of the issue date of the warrants.Warrants that have not been exercised within 5 years of theircreation become null and void. 8180 The extraordinary shareholders’ meeting of May 13, 2009 approved anextension of the warrant exercise period for these warrants up until May13, 2014, in accordance with Article 583 of the Companies Code and inaccordance with Article 21 of the Belgian Economic Recovery Law of March27, 2009.81 Idem footnote 80.Warrants issued in November 2005 for employees, directors,and consultantsBy a decision of the extraordinary shareholders’ meeting ofNovember 3, 2005, the Company issued 454,570 warrants givingthe beneficiaries the right to purchase shares of the Companyof class B or D. The warrants were granted with an exercise priceequal to the fair market price of the underlying common sharesat the date of grant.The warrants were granted to selected beneficiaries by decisionof the board of directors. Under this plan, 25% of the warrantsbecome vested on each anniversary of the date of the grant,provided that the beneficiary still has a relationship with theCompany via an employment contract agreement, a director’smandate or another collaboration agreement. The warrantscan only be exercised once vested, it being understood thatthey can only be exercised as from January 1 of the fourth yearfollowing the year in which they are granted (i.e., from January1, 2009 onwards for warrants granted in 2005). Non-exercisablewarrants become exercisable in case of an IPO or trade sale ofthe Company. All warrants were granted for free. The durationof the warrants is 5 years as of the issue date of the warrants.Warrants that have not been exercised within 5 years of theircreation become null and void. 82Warrants issued in February 2007 for employees, directors,and consultantsBy a decision of the extraordinary shareholders’ meeting ofFebruary 26, 2007, the Company issued 800,000 warrants givingthe beneficiaries the right to purchase common shares of theCompany.577,750 warrants were granted to selected beneficiaries bydecision of the board of directors. The weighted averageexercise price of the warrants was €6.50. The remaining222,250 warrants became null and void on September 26,2007. Under this plan, 25% of the warrants become vestedon each anniversary of the date of the grant, provided thatthe beneficiary still has a relationship with the Company viaan employment contract agreement, a director’s mandate oranother collaboration agreement. The warrants can only beexercised once vested, it being understood that they can onlybe exercised as from January 1 of the fourth year followingthe year in which they are granted (i.e., from January 1,2011 onwards for warrants granted in 2007). All warrants weregranted for free. The duration of the warrants is 10 years as of82 Idem footnote 80.188 • <strong>TiGenix</strong> • Rights Offering
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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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• TiGenix’ success depends on i
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Unaudited pro forma income statemen
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Recent developmentsAcquisition of C
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In this context, we would like to s
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Announcement of the results of theO
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After the Contribution andafter the
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ContributionContribution AgreementC
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Risk factorsAny investment in the P
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commercialisation of ChondroCelect,
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in delays in bringing products to t
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The Company cannot predict what eff
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y each of its patents and patent ap
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to exercise preferential subscripti
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this prospectus which is capable of
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• investment professionals fallin
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1. General information and informat
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1.4.2 Company documents and otherin
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• the granting of discharge of li
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• in case of registered Shares, t
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cast at the meeting. If the amount
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No one may cast a greater number of
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If a Belgian resident individual ne
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Belgium has concluded tax treaties
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3. Information on the Contributiona
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In this context, we would like to s
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TiGenix has a limited financial deb
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Thousands of Euro (€) TiGenix Cel
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3.5.2 Issuance Price and RatioThe i
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(c)Rules for subscriptionSubject to
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The Scrips Private Placement will o
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to comply with any of its obligatio
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3.11.2 Scenario 1: Existing Shareho
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• a pledge of Locked Shares to a
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4. General information about THECOM
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DateINCORPORATIONFebruary 21,2000Tr
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Upon completion of the IPO of TiGen
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Issue dateMay 14,2004April 20,2005T
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4.7.2 Voting rightsAs further descr
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can be obtained free of charge at t
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5.2.4 Composition of the Board of D
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Amonis. Mr. Duron has been CEO of K
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5.3.4 Nomination and remunerationco
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• investor relations: nurturing c
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The remuneration of the members of
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5.7.2 Shares and warrants held by e
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Cellerix EBIP 2010An EBIP for senio
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The minutes must also contain a jus
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6. Activities of Tigenix andits sub
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• Clinical stage pipeline. TiGeni
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6.3.3 Acquisition of CellerixAs a r
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Full thickness articular cartilage
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Fig. 6.2: Autologous Chondrocyte Im
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Preclinical work in a meniscus repa
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The Company is also ensuring high q
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Recognising the importance of pre-l
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In Spain, since the passage of Orde
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Fig. 6.6: ChondroMimetic procedure
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6.5.3 Commercial strategyBuilding o
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6.7 Manufacturing & logisticsEffici
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The international application WO06/
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ChondroMimetic competitionThe main
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in Cellerix’ GMP facility in Madr
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6.14.3 History and development of C
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TitleCountry/regionPatent/applicati
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Title“Cell populations having imu
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D. Trademarks of CellerixThe table
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Decision resources.Dell’Accio, F.
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Noyes, F. R., Barber-Westin, S. D.,
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Appendix 5: 2008, 2009 and2010 mana
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Contents1. The year in brief ......
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2. Financial informationa. The Inco
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The Directors shall call a Sharehol
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• Exercise price changed to 5.291
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10 • TiGenix • Rights Offering
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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Exceptionally, for the following re
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(d)(e)Duration: The Options Plan wi
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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eceipt sent to the number or addres
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THE COMPANYTiGenix NVRomeinse straa