D. Trademarks of CellerixThe table below gives an overview of Cellerix’ registered trademark portfolio:Country Trademark Registration number ClassesSpain (Commercial Name) CELLERIX 260.857(X) 5 & 42Europe CELLERIX 4,142,774 5, 10 & 42Spain RETROFECT 2.507.407(5) 35Europe EFISEL 4.68.77.61 10Europe IDRYON 4.68.77.78 10Europe ONTARIL 5,652,599 5Europe MIREDAL 5,652,698 5Europe LIVING MEDICINES 4.67.92.54 16 & 35Europe CELLERIX LIVING MEDICINES 6,879,721 5, 10 & 42Europe ALOCELLIX 7,328,164 3 & 5Europe ADICELL-X 7,328,693 3 & 5Europe CELLERIX (Graphic) 7,335,888 5, 10 & 42Europe ALOFISEL 7,352,081 3 & 5USA CELLERIX (Graphic) 78/920,563 (Registration Pending) 5 & 42USA ONTARIL 77/370,501 (Registration Pending) 5USA CELLERIX LIVING MEDICINES 77/461,497 (Registration Pending) 5 & 42241 •
Appendix 4: BibliographyThe following is a bibliography from which certain information in this prospectus has been derived.2005 Healthpoint Capital Orthopedic Market ReportAlford, J. W. and Cole, B. J. (2005) Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatmentoptions. Am.J.Sports Med. 33: 295-306Alford, J. W. and Cole, B. J. (2005) Cartilage restoration, part 2: techniques, outcomes, and future directions. Am.J.Sports Med. 33: 443-460American Academy of Orthopaedic Surgeons, OA of the Knee – State of the Condition, 2004Arden, N. & Nevitt, M. C.(2006) Best Pract Res Clin Rheumatol, 20(1) 3-25Aroen, A., Loken, S., Heir, S., Alvik, E., Ekeland, A., Granlund, O. G., and Engebretsen, L. (2004) Articular cartilage lesions in993 consecutive knee arthroscopies. Am.J.Sports Med. 32: 211-215Best Pract Res Clin Haematol. 2011 Mar;24(1):49-57. Epub 2011 Feb 23. “Mesenchymal stem cells and autoimmune diseases.”Biotech in Autoimmune/Inflammatory Disease 2006 2nd Edition Arrowhead Publishers.Bongartz, 2009.Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., and Peterson, L. (6-10-1994) Treatment of deep cartilage defects in theknee with autologous chondrocyte transplantation. N.Engl.J.Med. 331: 889-895Brittberg, M. (2008) Autologous chondrocyte implantation--technique and long-term follow-up. Injury 39 Suppl 1: S40-S49Buckwalter, J. A., Saltzman, C., & Brown, T., (2004) The impact of osteoarthritis: Implications for research. Clin. Orthop. Relat. Res (427)Suppl, S6-15.Buckwalter, J. A., Mankin, H. J., and Grodzinsky, A. J. (2005) Articular cartilage and osteoarthritis. Instr.Course Lect. 54: 465-480Burnett, S., Cooper, C., and Spector, T. (1994) A radiographic atlas of osteoarthritis. London: SpringerCicuttini, F., Ding, C., Wluka, A., Davis, S., Ebeling, P. R., and Jones, G. (2005) Association of cartilage defects with loss of knee cartilage inhealthy, middle-age adults: a prospective study. Arthritis Rheum. 52: 2033-2039Clar, C., Cummins, E., McIntyre, L., Thomas, S., Lamb, J., Bain, L., Jobanputra, P., and Waugh, N. (2005) Clinical and cost-effectiveness ofautologous chondrocyte implantation for cartilage defects in knee joints: systematic review and economic evaluation. Health Technol.Assess. 9: 1-98Curl, W. W., Krome, J., Gordon, E. S., Rushing, J., Smith, B. P., and Poehling, G. G. (1997) Cartilage injuries: a review of 31,516 kneearthroscopies. Arthroscopy 13: 456-460Curr Opin Allergy Clin Immunol. 2009 Dec;9(6):537-43. “Intralymphatic immunotherapy.”Senti G, Johansen P, Kündig TM.Cytotherapy. 2007;9(8):755-70. Epub 2007 Oct 4.”Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment ofpediatric cancer.” Dohnal AM, Witt V, Hügel H, Holter W, Gadner H, Felzmann T.Datamonitor, 2009Datamonitor. “Stakeholder Opinions: Autoimmune Diseases in Emerging Markets”. May <strong>2010</strong>.242 • <strong>TiGenix</strong> • Rights Offering
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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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• TiGenix’ success depends on i
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Unaudited pro forma income statemen
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Recent developmentsAcquisition of C
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In this context, we would like to s
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Announcement of the results of theO
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After the Contribution andafter the
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ContributionContribution AgreementC
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Risk factorsAny investment in the P
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commercialisation of ChondroCelect,
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The Company cannot predict what eff
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y each of its patents and patent ap
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this prospectus which is capable of
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1. General information and informat
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cast at the meeting. If the amount
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No one may cast a greater number of
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If a Belgian resident individual ne
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Belgium has concluded tax treaties
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3. Information on the Contributiona
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In this context, we would like to s
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TiGenix has a limited financial deb
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Thousands of Euro (€) TiGenix Cel
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3.5.2 Issuance Price and RatioThe i
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(c)Rules for subscriptionSubject to
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The Scrips Private Placement will o
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to comply with any of its obligatio
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4. General information about THECOM
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DateINCORPORATIONFebruary 21,2000Tr
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Upon completion of the IPO of TiGen
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Issue dateMay 14,2004April 20,2005T
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can be obtained free of charge at t
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Cellerix EBIP 2010An EBIP for senio
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The minutes must also contain a jus
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6. Activities of Tigenix andits sub
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• Clinical stage pipeline. TiGeni
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6.3.3 Acquisition of CellerixAs a r
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Full thickness articular cartilage
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Fig. 6.2: Autologous Chondrocyte Im
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Preclinical work in a meniscus repa
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The Company is also ensuring high q
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In Spain, since the passage of Orde
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Fig. 6.6: ChondroMimetic procedure
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6.5.3 Commercial strategyBuilding o
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6.7 Manufacturing & logisticsEffici
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The international application WO06/
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ChondroMimetic competitionThe main
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in Cellerix’ GMP facility in Madr
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6.14.3 History and development of C
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The table below gives an overview o
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Prevalence No. of cases (2010) Esti
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In developing Cx601, Cellerix has b
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population, methods for the isolati
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• Cimzia (certolizumab) - UCB: Al
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Spanish Ministry of Education and S
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8.1.5 Notes to consolidated financi
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operating results and operating pla
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Business combination Cellerix SADes
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Weighted averageexercise priceTOTAL
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the respective issue date of the wa
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